ArticleThe EMBO journal1993
Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 85 citations in OpenAlex.
- Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.American journal of human genetics · 2017Article
- ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells.Oncology letters · 2016Article
- Novel copy-number variants in a population-based investigation of classic heterotaxy.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Article
- Article
- Expression and function of Nkx6.3 in vertebrate hindbrain.Brain research · 2008Article
- Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum.Molecular and cellular biology · 2008Article
- Specificity of four monoclonal anti-NKx6-1 antibodies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube.Gene expression patterns : GEP · 2007Article
- CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Tlx controls proliferation and patterning of lateral telencephalic progenitor domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally.Molecular and cellular biology · 2001Article
- A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- rRNA-complementarity in the 5' untranslated region of mRNA specifying the Gtx homeodomain protein: evidence that base- pairing to 18S rRNA affects translational efficiency.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.Genes & development · 1998Article
- Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Homeobox genes and male reproductive development.Journal of assisted reproduction and genetics · 1996Review
- Quantitative discrimination of MEF2 sites.Molecular and cellular biology · 1996Article
- Serum induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation.Molecular and cellular biology · 1995Article
- Csx: a murine homeobox-containing gene specifically expressed in the developing heart.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although it is likely that a highly complex network of transcription factors acts in concert during mammalian brain development, relatively few such genes have been characterized to date. We describe here a novel murine homeobox gene, denoted Gtx, which in adult animals is specifically expressed within glial cells of the central nervous system, including the forebrain, and in germ cells of the testis. Gtx resides on chromosome 7 and does not cosegregate with any previously mapped homeobox gene. The amino acid sequence of the predicted protein encoded by Gtx is highly divergent from that of any other known homeobox genes. The Gtx homeodomain contains unique residues at positions predicted to contact DNA bases. It did not bind to known target sites for other homeobox genes in vitro but bound with high affinity to the MEF-2 motif, a binding site for the serum response factor-related proteins. GTX efficiently competed with RSRF to bind the MEF-2 element in vitro. Co-transfection of Gtx prevented the serum-induced activation of the MEF-2-containing reporter genes. Although the true biological role of Gtx is not known, these results suggest that Gtx is a novel cell-type specific homeobox gene that has the potential to act as a transcriptional repressor for a subset of serum-inducible genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.