ArticleThe EMBO journal1993
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 83 citations in OpenAlex.
- A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.Molecular and cellular biology · 2004Article
- Review
- Article
- Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone.The Biochemical journal · 2001Article
- Regulation of the mdm2 oncogene by thyroid hormone receptor.Molecular and cellular biology · 1999Article
- Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo.The EMBO journal · 1998Article
- Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression.Molecular and cellular biology · 1997Article
- Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus.Molecular and cellular biology · 1996Article
- The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor.Endocrine · 1996Article
- Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid.Molecular and cellular biology · 1996Article
- OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Article
- Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.The EMBO journal · 1994Article
- Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.The EMBO journal · 1994Article
- Improved method for PCR-mediated site-directed mutagenesis.Nucleic acids research · 1994Article
- Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.Molecular and cellular biology · 1994Article
- Preparation of unoccupied thyroid-hormone receptor.The Biochemical journal · 1994Article
- Negative regulation of transcription in eukaryotes.The Biochemical journal · 1993Review
- The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.The EMBO journal · 1993Article
- Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
V-erbA is thought to be an antagonist of thyroid hormone receptor (T3R) function. Here we show that unliganded T3R, but not v-erbA, suppresses retinoic acid (RA)-dependent induction of the RAR-beta 2 promoter by competing for the common dimerization partner, the retinoid X receptor (RXR). Firstly, T3R suppression can be alleviated by co-transfection of RXR. Secondly, T3R, but not v-erbA, competes with RAR for RXR and causes the dissociation of a preformed RAR/RXR-RARE ternary complex in vitro. A single point mutation located in the dimerization interface of v-erbA (Pro349 to Ser) abolishes the transdominant phenotype when introduced at the respective position in T3R. The hypertransforming v-erbA variant r12, in which this mutation is reversed (Ser349 to Pro) suppresses RA-induced differentiation in chicken erythroid progenitors, while v-erbA does not. Our data thus suggest that unliganded T3R and v-erbA act as dominant suppressors through mechanistically distinct pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.