ArticleBritish journal of pharmacology1993
Beta-adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 162 citations in OpenAlex.
- Short-term effects of inhaled salbutamol on autonomic cardiovascular control in healthy subjects: a placebo-controlled study.British journal of clinical pharmacology · 2009Trial
- Contribution of nitric oxide to beta2-adrenoceptor mediated vasodilatation in human forearm arterial vasculature.British journal of clinical pharmacology · 1999Trial
- Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins.British journal of clinical pharmacology · 1999Trial
- Nitric oxide mediated venodilator effects of nebivolol.British journal of clinical pharmacology · 1994Trial
- Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder.BJPsych open · 2021Article
- GROWTH AND CHARACTERIZATION OF A TISSUE-ENGINEERED CONSTRUCT FROM HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS.Biulleten' Sibirskoi meditsiny · 2020Article
- Rat mesenteric small artery neurogenic dilatation is predominantly mediated by βThe Journal of physiology · 2019Article
- PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.British journal of pharmacology · 2017Article
- Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.British journal of pharmacology · 2016Article
- Vascular response of ruthenium tetraamines in aortic ring from normotensive rats.Arquivos brasileiros de cardiologia · 2015Article
- Adrenoreceptors and nitric oxide in the cardiovascular system.Frontiers in physiology · 2013Review
- β₁-Adrenoceptor stimulation suppresses endothelial IK(Ca)-channel hyperpolarization and associated dilatation in resistance arteries.British journal of pharmacology · 2013Article
- Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.British journal of pharmacology · 2013Article
- Impaired β-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K(Ca) channel activity.Pharmacological research · 2012Article
- Fatigue and muscle atrophy in a mouse model of myasthenia gravis is paralleled by loss of sarcolemmal nNOS.PloS one · 2012Article
- Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.British journal of pharmacology · 2011Article
- Effect of inhibition of extracellular signal-regulated kinase on relaxations to beta-adrenoceptor agonists in porcine isolated blood vessels.British journal of pharmacology · 2009Article
- A role for cyclooxygenase in aging-related changes of beta-adrenoceptor-mediated relaxation in rat aortas.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
- Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries.British journal of pharmacology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Isoprenaline (10(-9)-10(-5) M) relaxed rat isolated mesenteric resistance arteries pre-contracted with K+ (30-60 mM) (p EC50 (M) 8.03 +/- 0.40; maximum relaxation 66.79 +/- 2.43%, n = 7). This relaxation was partially attenuated by the nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 10(-4) M). 2. The beta 2-adrenoceptor agonist, salbutamol (10(-9)-10(-5) M), produced a modest maximum relaxation (35.93 +/- 2.93%), which was not sensitive to L-NAME. 3. The beta 1-adrenoceptor agonist, dobutamine (10(-9)-10(-5) M), relaxed arteries precontracted with K+. This relaxation was abolished by L-NAME (10(-4) M) and also by propranolol (10(-6) M), but not affected by D-NAME (10(-4) M). The inhibition by L-NAME was partially reversed by L-arginine (10(-3) M). Removal of the endothelium severely attenuated relaxation to dobutamine. 4. Contractile responses to depolarizing K+ solutions were enhanced by the addition of L-NAME, and also by removal of the endothelium. 5. The above findings demonstrate that beta 1-adrenoceptor causes relaxation via NO release from the endothelium of rat mesenteric resistance arteries. In addition, contraction to K+ is modified by release of NO from the endothelium, possibly in response to tension development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.