ArticleJapanese journal of cancer research : Gann1993
Reduced expression of nm23 is associated with metastasis of human gastric carcinomas.
Article in Japanese journal of cancer research : Gann, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 130 citations in OpenAlex.
- NDPKA is not just a metastasis suppressor - be aware of its metastasis-promoting role in neuroblastoma.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.Clinical proteomics · 2012Article
- Genomic and genetic alterations influence the progression of gastric cancer.World journal of gastroenterology · 2011Review
- Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.World journal of gastroenterology · 2008Article
- Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer.Cancer science · 2007Article
- Cellular and molecular aspects of gastric cancer.World journal of gastroenterology · 2006Review
- Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer.Cancer science · 2005Article
- Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.Cancer science · 2004Article
- Increased nm23 immunoreactivity is associated with selective inhibition of systemic tumour cell dissemination.Journal of clinical pathology · 2002Article
- Clinical significance of nm23 expression and chromosome 17 numerical aberrations in primary gastric cancer.Medical oncology (Northwood, London, England) · 2002Article
- Article
- Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival.BMC cancer · 2001Article
- nm23-H1 expression defines a high-risk subpopulation of patients with early-stage epithelial ovarian carcinoma.British journal of cancer · 2000Article
- Expression of nm23-H1 in colorectal cancer: no association with metastases, histological stage, or survival.Surgery today · 1999Article
- Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression.Journal of gastroenterology · 1997Article
- Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23).Clinical & experimental metastasis · 1997Article
- NM-23 H1 immunohistochemistry is not useful as predictor of metastatic potential of colorectal cancer.British journal of cancer · 1996Article
- Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion.British journal of cancer · 1996Article
- Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition of a c-myc regulatory element.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Correlation between nm23 protein and several cell adhesion molecules in human gastric carcinoma.Japanese journal of cancer research : Gann · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced expression of nm23 gene is implicated in high metastatic potential in a variety of malignancies. To elucidate the role of nm23 in human gastric carcinomas, we examined loss of heterozygosity (LOH) of nm23 gene by Southern blotting, nm23 mRNA expression by Northern blotting and nm23 protein expression by Western blotting as well as immunohistochemistry in both primary and metastatic tumors. LOH of nm23 gene was found in 2 (8%) out of the 23 informative gastric carcinomas. Twenty-two (84%) out of the 26 cases expressed nm23 mRNA at higher levels in primary tumor tissue than in corresponding non-neoplastic mucosa. No obvious correlation was observed between clinico-pathological features and LOH of nm23 gene or nm23 mRNA expression. On the other hand, 52% of the gastric carcinomas showed reduction of nm23 immunoreactivity in the metastatic tumor of regional lymph nodes, as compared to the primary tumor. Interestingly, 71% of the gastric carcinomas showed weaker nm23 immunoreactivity in the liver metastasis than in the primary tumor. These results suggest that nm23 overexpression is linked with development of gastric carcinomas and the decrease in expression of nm23 participates in metastasis.
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