ArticleAmerican journal of human genetics1993
Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees.
Article in American journal of human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The genetic basis of onset age in schizophrenia: evidence and models.Frontiers in genetics · 2023Review
- Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.Translational psychiatry · 2015Review
- Amphiphysin I but not dynamin I nor synaptojanin mRNA expression increased after repeated methamphetamine administration in the rat cerebrum and cerebellum.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Dopamine partial agonists: a new class of antipsychotic.CNS drugs · 2004Review
- Molecular genetics of schizophrenia: a critical review.Journal of psychiatry & neuroscience : JPN · 2003Review
- The role of candidate genes in the etiology of schizophrenia.Molecular medicine (Cambridge, Mass.) · 1996Review
- Mitochondrial involvement in schizophrenia and other functional psychoses.Neurochemical research · 1996Article
- Molecular genetics of psychopathologies: a search for simple answers to complex problems.Behavior genetics · 1996Article
- A search for association between schizophrenia and dopamine-related alleles.European archives of psychiatry and clinical neuroscience · 1996Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Alterations in dopamine neurotransmission have been strongly implicated in the pathogenesis of schizophrenia for nearly 2 decades. Recently, the genes for five dopamine receptors have been cloned and characterized, and genetic and physical map information has become available. Using these five loci as candidate genes, we have tested for genetic linkage to schizophrenia in nine multigenerational families which include multiple affected individuals. In addition to testing conservative disease models, we have used a neurophysiological indicator variable, the P50 auditory evoked response. Deficits in gating of the P50 response have been shown to segregate with schizophrenia in this sample and may identify carriers of gene(s) predisposing for schizophrenia. Linkage results were consistently negative, indicating that a defect at any of the actual receptor sites is unlikely to be a major contributor to schizophrenia in the nine families studied.
Indexed as
Identifiers
8094267PMC1682188What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.