ArticleClinical & experimental metastasis1993
PCNA levels in neuroblastoma are increased in tumors with an amplified N-myc gene and in metastatic stage tumors.
Article in Clinical & experimental metastasis, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.Current treatment options in oncology · 2021Review
- Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.Cancer discovery · 2018Article
- Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling.Molecules and cells · 2016Article
- Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma.Experimental & molecular medicine · 2012Article
- Prognostic significance of the proliferative activity in neuroblastoma.The American journal of pathology · 1997Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
N-myc oncogene amplification in neuroblastoma has been found to be significantly associated with advanced stage disease and tumor progression. However, there is a lack of data on tumors, regarding the relationship between N-myc gene amplification and proliferation activity. Proliferating cell nuclear antigen (PCNA) is a proliferation-induced 36 kD nuclear protein that is the auxiliary component of DNA polymerase delta. PCNA levels in tissues have been found to correlate with proliferative activity. We have examined PCNA levels in neuroblastomas in relation to N-myc gene amplification and tumor stage. Statistically, significantly higher levels of PCNA were observed in tumors with an amplified N-myc gene relative to tumors with a single gene copy. The highest levels of PCNA were observed in advanced stage tumors with an amplified N-myc gene. Treatment of neuroblastoma cells in culture with retinoic acid, which induces differentiation, resulted in a substantial decrease in PCNA. Our results suggest that PCNA levels may reflect differences in proliferative activity between neuroblastomas, related to stage of the disease and to N-myc gene copy number.
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