ArticleMammalian genome : official journal of the International Mammalian Genome Society1993
Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Re-localization of Actsk-1 to mouse chromosome 8, a new region of homology with human chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Angiotensinogen is an alpha 2-globulin involved in the maintenance of blood pressure and electrolyte balance. We have refined the position of the mouse angiotensinogen locus (Agt) on Chromosome (Chr) 8 and have also confirmed the assignment of the human angiotensinogen locus (AGT) to Chr 1. The segregation of several restriction fragment length variants (RFLVs) was followed in two interspecific backcross sets and in four recombinant inbred (RI) mouse sets. Analysis of the segregation patterns closely linked Agt to Aprt and Emv-2, which places the angiotensinogen locus on the distal end of mouse Chr 8. Additionally, a literature search has revealed that the strain distribution pattern (SDP) for the mouse skeletal alpha-actin locus 1 (Actsk-1, previously Acta1, Acta, or Acts) is nearly identical to the SDP for Agt in two RI sets. On the basis of this information we were able to reassign Actsk-1 to mouse Chr 8. By screening a panel of human-mouse somatic cell hybrids, we confirmed that the human angiotensinogen locus lies on Chr 1. This information describes a new region of conserved linkage homology between mouse Chr 8 and human Chr 1. It also defines the end of a large region of conserved linkage homology between mouse Chr 8 and human Chr 16.
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