ArticleProceedings of the National Academy of Sciences of the United States of America1993
A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry.Endocrine pathology · 2021Review
- The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.eLife · 2015Article
- Review
- Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Translational research in endocrine surgery.Surgical oncology clinics of North America · 2013Review
- Article
- Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine.American journal of human genetics · 1997Article
- Presymptomatic genetic screening in families with multiple endocrine neoplasia type 2.Journal of molecular medicine (Berlin, Germany) · 1995Article
- Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A.Annals of surgery · 1994Article
- Long segment and short segment familial Hirschsprung's disease: variable clinical expression at the RET locus.Journal of medical genetics · 1994Article
- A multiple interval physical map of the pericentromeric region of human chromosome 10.Human genetics · 1994Article
- The organisation of repetitive sequences in the pericentromeric region of human chromosome 10.Nucleic acids research · 1993Article
- Construction of radiation-reduced hybrids and their use in mapping of microclones from chromosome 10p11.2-q11.2.The Japanese journal of human genetics · 1993Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The genetic loci RET, D10S94, and D10S102 from human chromosome 10q11.2 are very closely linked to a locus responsible for the multiple endocrine neoplasia type 2 (MEN2A and MEN2B) and medullary thyroid carcinoma (MTC1) familial cancer syndromes. We have constructed a 1.5-megabase contig consisting of six genomic yeast artificial chromosome clones which include these loci and define their physical order. A critical crossover event has been identified within the map interval; this event places the MEN2A locus centromeric to D10S102 and defines the orientation of the physical map on the chromosome. The orientation of the contig and order of the markers are centromere-RET-D10S94-D10S102-telomere. In addition, a microsatellite repeat polymorphism with a heterozygosity of 71% at the RET locus and a restriction fragment length polymorphism with a heterozygosity of 42% detected by a lambda clone from the D10S94 locus have been developed for high-resolution genetic linkage mapping and predictive diagnostic testing. These data place three important markers on a contiguous physical map, narrow the MEN2 disease locus interval, and provide a framework for further candidate gene identification efforts. Placement of these genetic loci along a clone-based map and continued expansion of the contig will also facilitate efforts to determine the relationship of physical to genetic distance near the centromeres of human chromosomes.
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