ArticleProceedings of the National Academy of Sciences of the United States of America1993
In vivo response of murine gamma delta T cells to a heat shock protein-derived peptide.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023Review
- γδ T cell costimulatory ligands in antitumor immunity.Exploration of immunology · 2022Article
- A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.Immunity · 2018Article
- γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.Molecular immunology · 2014Article
- γδ-T cells: an unpolished sword in human anti-infection immunity.Cellular & molecular immunology · 2013Review
- Peptide antigens for gamma/delta T cells.Cellular and molecular life sciences : CMLS · 2011Review
- gammadelta T lymphocytes-selectable cells within the innate system?Journal of clinical immunology · 2007Review
- Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan.Infection and immunity · 2004Article
- In vitro responsiveness of gammadelta T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1(+) cells.Infection and immunity · 2001Article
- Murine gamma delta T lymphocytes elicited during Plasmodium yoelii infection respond to Plasmodium heat shock proteins.Infection and immunity · 1999Article
- Gamma delta T cells in infection-induced and autoimmune-induced testicular inflammation.Immunology · 1998Article
- Gammadelta+ and CD4+ alphabeta+ human T cell subset responses upon stimulation with various Mycobacterium tuberculosis soluble extracts.Clinical and experimental immunology · 1998Article
- Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells.Journal of virology · 1996Article
- Infection of Mycobacterium bovis bacillus Calmette-Guérin in antibody-mediated gamma delta T-cell-depleted mice.Immunology · 1995Article
- The enigmatic specificity of gamma delta T cells.Immunologic research · 1995Review
- Heat shock protein 70-associated peptides elicit specific cancer immunity.The Journal of experimental medicine · 1993Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent results suggested that a large subset of heat shock protein HSP-60 reactive peripheral lymphoid gamma delta T cells preexists in normal adult mice, all members of which respond to a single segment of this common HSP. However, the experimental evidence supporting this idea involved in vitro peptide responses of gamma delta T-cell hybridomas generated from unprimed spleen cells. Here, we report an attempt to elicit a gamma delta T-cell response in vivo by stimulation of adult C57BL/10 mice with HSP-60 or an HSP-60-derived peptide fragment comprising amino acids 180-196 of mycobacterial HSP-60. Whereas no gamma delta T-cell response was detectable in mice injected with the intact protein, stimulation with the peptide altered the reactive gamma delta T-cell population in vivo. These changes were detected among hybridomas generated with cells restimulated in vitro and included a large increase in hybridizable gamma delta T cells, a nearly maximal increase in the relative frequency of HSP-60-reactive cells, and structural changes in expressed T-cell receptors of HSP-60-reactive cells. Interestingly, we failed to elicit a detectable alpha beta T-cell response to the particular peptide stimulatory for gamma delta T cells, although at least three other HSP-60 epitopes were recognized. Our data show that normal gamma delta T cells can respond in vivo to small peptide antigens. The gamma delta T-cell response to the HSP-60-derived peptide studied here is apparently independent of antigen-specific alpha beta T-cell reactivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.