ArticleProceedings of the National Academy of Sciences of the United States of America1993
The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 118 citations in OpenAlex.
- Suboptimal Intermediates Underlie Evolution of the Bicoid Homeodomain.Molecular biology and evolution · 2021Article
- The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution.Frontiers in microbiology · 2017Review
- Distinct molecular strategies for Hox-mediated limb suppression in Drosophila: from cooperativity to dispensability/antagonism in TALE partnership.PLoS genetics · 2013Article
- The origin of patterning systems in bilateria-insights from the Hox and ParaHox genes in Acoelomorpha.Genomics, proteomics & bioinformatics · 2011Review
- Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Duplicated Hox genes in the spider Cupiennius salei.Frontiers in zoology · 2007Article
- Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.PloS one · 2007Article
- The duplication of the Hox gene clusters in teleost fishes.Theory in biosciences = Theorie in den Biowissenschaften · 2004Article
- Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters.Genome biology · 2003Article
- Sequence of the Tribolium castaneum homeotic complex: the region corresponding to the Drosophila melanogaster antennapedia complex.Genetics · 2002Article
- HOX genes in the sepiolid squid Euprymna scolopes: implications for the evolution of complex body plans.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Classification and phylogeny of the MADS-box multigene family suggest defined roles of MADS-box gene subfamilies in the morphological evolution of eukaryotes.Journal of molecular evolution · 1996Article
- Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Genetic redundancy caused by gene duplications and its evolution in networks of transcriptional regulators.Biological cybernetics · 1996Article
- Evolution of Antennapedia-class homeobox genes.Genetics · 1996Article
- Identification of planarian homeobox sequences indicates the antiquity of most Hox/homeotic gene subclasses.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Molecular pathways to parallel evolution: I. Gene nexuses and their morphological correlates.Journal of molecular evolution · 1994Article
- The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.The EMBO journal · 1994Article
- The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.The EMBO journal · 1994Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The developmental control genes containing an Antennapedia-type homeobox are clustered in insects and vertebrates. The evolution of these genes was studied by the construction of evolutionary trees and by statistical geometry in sequence space. The comparative analysis of the homeobox sequences reveals the subdivision of the Antennapedia-type homeobox genes into three classes early in metazoan evolution. This observation suggests an important function of these genes even in the most primitive metazoans. Subsequent duplication events generated a cluster of at least five homeobox genes in the last common ancestor of insects and vertebrates. These genes later independently gave rise to the 13 groups of paralogous genes in vertebrates and to the 11 Antennapedia-type genes in the Drosophila complexes.
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