ArticleProceedings of the National Academy of Sciences of the United States of America1993
Serotonin receptor cDNA cloned from Lymnaea stagnalis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Understanding Target-Specific Effects of Antidepressant Drug Pollution on Molluscs: A Systematic Review Report.Toxics · 2025Review
- Development of 2-Aminotetralin-Type Serotonin 5-HTACS chemical neuroscience · 2024Article
- Article
- Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol.PloS one · 2023Article
- Identification, characterization, and expression analysis of a serotonin receptor involved in the reproductive process of the Pacific abalone, Haliotis discus hannai.Molecular biology reports · 2020Article
- Article
- Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum.PloS one · 2013Article
- Neuronal control of pedal sole cilia in the pond snail Lymnaea stagnalis appressa.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Molecular characterization and analysis of a truncated serotonin receptor gene expressed in neural and reproductive tissues of abalone.Histochemistry and cell biology · 2009Article
- Cloning and immunoreactivity of the 5-HT 1Mac and 5-HT 2Mac receptors in the central nervous system of the freshwater prawn Macrobrachium rosenbergii.The Journal of comparative neurology · 2009Article
- Conservation of structure, signaling and pharmacology between two serotonin receptor subtypes from decapod crustaceans, Panulirus interruptus and Procambarus clarkii.The Journal of experimental biology · 2008Article
- Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors.Invertebrate neuroscience : IN · 2006Article
- Immunocytochemical localization of serotonin in embryos, larvae and adults of the lancelet, Branchiostoma floridae.The Histochemical journal · 2001Article
- Cloning and functional expression of an Aplysia 5-HT receptor negatively coupled to adenylate cyclase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans.Journal of molecular neuroscience : MN · 1997Article
- Modulation and selection of neurotransmitter responses during synapse formation between identified leech neurons.Cellular and molecular neurobiology · 1996Article
- A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Inhibition and sex specific induction of spawning by serotonergic ligands in the zebra mussel Dreissena polymorpha (Pallas).Experientia · 1994Article
- The relations between neuroscience and human behavioral science.Journal of the experimental analysis of behavior · 1994Review
- Multiple serotonergic mechanisms contributing to sensitization in aplysia: evidence of diverse serotonin receptor subtypes.Learning & memory (Cold Spring Harbor, N.Y.)Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Serotonin (5-HT) is a major neurotransmitter that influences various behaviors, neuronal plasticity, learning, and memory in molluscs. Although the physiology of 5-HT transmission in molluscs is well studied, little is known about the pharmacology and diversity of the 5-HT receptor system. Based on the high homology of genes coding for guanine nucleotide-binding protein (G protein)-coupled receptors, we have cloned a gene for the Lymnaea stagnalis 5-HT (5HTlym) receptor. The putative receptor protein, 509 amino acids long, has highest homology with the Drosophila 5-HT receptors and mammalian 5HT1 receptors. As revealed by RNA blot-hybridization analysis, two mRNA species of 2.3 and 3.2 kb are detected in the central nervous system of Lymnaea. Transient expression of 5HTlym in COS-7 cells showed saturable [3H]lysergic acid diethylamide binding with an estimated dissociation constant of 0.9 nM. The 5HTlym receptor exhibited a mixed 5HT-like pharmacology that cannot be precisely categorized with existing mammalian classification nomenclature. However, the 5HTlym receptor does display some characteristics that have been attributed to the putative mammalian vascular 5HT1-like receptor.
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