ArticleMolecular and cellular biology1993
Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 137 citations in OpenAlex.
- Article
- Retinoic Acid Regulates Spermiogenesis Via Hoxb1 and Shh Signaling in Testicular Germ Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- HOX genes: Major actors in resistance to selective endocrine response modifiers.Biochimica et biophysica acta · 2016Review
- Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.Molecular oncology · 2015Article
- The development and growth of tissues derived from cranial neural crest and primitive mesoderm is dependent on the ligation status of retinoic acid receptor γ: evidence that retinoic acid receptor γ functions to maintain stem/progenitor cells in the absence of retinoic acid.Stem cells and development · 2015Article
- YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.PloS one · 2014Article
- Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.Experimental cell research · 2014Article
- Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid.The Journal of biological chemistry · 2011Article
- Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.PloS one · 2011Article
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.The Journal of experimental medicine · 2006Article
- Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments.Molecular and cellular biology · 2004Article
- Review
- Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.Molecular and cellular biology · 2000Article
- Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.Molecular and cellular biology · 2000Article
- Review
- A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.Molecular and cellular biology · 1998Article
- Selectivity, sharing and competitive interactions in the regulation of Hoxb genes.The EMBO journal · 1998Article
- Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox genes play an important role in the process of vertebrate pattern formation, and their expression is intricately regulated both temporally and spatially. All-trans-retinoic acid (RA), a physiologically active metabolite of vitamin A, affects the expression of a large number of Hox genes in vitro and in vivo. However, the regulatory mechanisms underlying the RA response of these genes have not been extensively studied, and no response element for RA receptors (RARs) has been characterized in a Hox regulatory region. The expression of murine Hox-4.2 and its human homolog, HOX4B, is increased in embryonal carcinoma (EC) cell lines upon RA treatment (M. S. Featherstone, A. Baron, S. J. Gaunt, M.-G. Mattei, and D. Duboule, Proc. Natl. Acad. Sci. USA 85:4760-4764, 1988; A. Simeone, D. Acampora, V. Nigro, A. Faiella, M. D'Esposito, A. Stornaiuolo, F. Mavilio, and E. Boncinelli, Mech. Dev. 33:215-228, 1991). Using transient expression assays, we showed that luciferase reporter gene constructs carrying genomic sequences located upstream of Hox-4.2 responded to RA in murine P19 EC cells. A 402-bp NcoI fragment was necessary for the RA responsiveness of reporter constructs. This fragment contained a regulatory element, 5'-AGGTGA(N)5AGGTCA-3', that closely resembles the consensus sequence for an RA response element. The Hox-4.2 RA response element was critical for the RA induction and specifically bound RARs. In addition, the response to RA could be inhibited by expressing a dominant negative form of RAR alpha in transfected P19 EC cells. These results suggested that Hox-4.2 is a target for RAR-mediated regulation by RA.
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