ArticleJournal of virology1993
Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- Interrogating Adaptive Immunity Using LCMV.Current protocols in immunology · 2020Article
- The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection.Frontiers in immunology · 2020Article
- Review
- Short noncoding DNA fragments improve the immune potency of electroporation-mediated HBV DNA vaccination.Gene therapy · 2014Article
- Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice.Frontiers in immunology · 2013Article
- Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus.Journal of virology · 2012Article
- Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.Journal of neuroimmunology · 2010Article
- Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production.Journal of virology · 2009Article
- "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.PloS one · 2007Article
- B2 but not B1 cells can contribute to CD4+ T-cell-mediated clearance of rotavirus in SCID mice.Journal of virology · 2001Article
- Transient control of a virus-induced immunopathology by genetic immunosuppression.Gene therapy · 2000Article
- Host factors influencing viral persistence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus.Journal of virology · 2000Article
- Viral persistence in vivo through selection of neutralizing antibody-escape variants.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease.Journal of virology · 1997Article
- Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice.Journal of virology · 1997Article
- Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice.Journal of virology · 1997Article
- Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells.Journal of virology · 1997Article
- Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice infected intracerebrally with lymphocytic choriomeningitis virus (LCM virus) develop a characteristic central nervous system disease and usually die. If the intravenous or intraperitoneal route is used, the infection leads to less severe clinical signs and the virus is eliminated. Illness and virus clearance are immunological phenomena, which are assumed to be caused exclusively by CD8+ T lymphocytes. In contrast, of the two phases of a delayed-type hypersensitivity reaction caused by inoculation of the virus into the mouse's foot, only the first is mediated by CD8+ cells, whereas the second is mediated by CD4+ cells. We have examined LCM virus-specific immune responses in mice devoid of CD8+ T lymphocytes as a result of disruption of the beta 2-microglobulin gene. As expected, the virus persisted but footpad swelling did not occur, although intracerebral infection resulted in CD4+ T-lymphocyte-mediated illness and antiviral antibodies were produced. Different results had been obtained by Fung-Leung et al. (W.-P. Fung-Leung, T. M. Kündig, R. M. Zinkernagel, and T. W. Mak, J. Exp. Med. 174:1425-1429, 1991), who, is essentially identical experiments but with mice lacking CD8+ T lymphocytes as a result of disruption of the Lyt-2-encoding gene, recorded control of the infection and development of a local delayed-type hypersensitivity reaction. We consider these differences important, because they provide us with clues that may help to understand the mode of action of the CD8+ T cells in cell-mediated antiviral immunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.