ArticleThe Biochemical journal1994
Relationship between latency and period for 5-hydroxytryptamine-induced membrane responses in the Calliphora salivary gland.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 32 citations in OpenAlex.
- STIM and Orai proteins and the non-capacitative ARC channels.Frontiers in bioscience (Landmark edition) · 2012Review
- Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations.The Journal of physiology · 2011Article
- Ca2+ influx does more than provide releasable Ca2+ to maintain repetitive spiking in human umbilical vein endothelial cells.The Biochemical journal · 1996Article
- Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells.The Biochemical journal · 1996Article
- Evidence for a non-capacitative Ca2+ entry during [Ca2+] oscillations.The Biochemical journal · 1996Article
- Ca2+ entry modulates oscillation frequency by triggering Ca2+ release.The Biochemical journal · 1996Article
- Initiation sites for Ca2+ signals in endothelial cells.Pflugers Archiv : European journal of physiology · 1996Article
- Exploring the unique features of the ARC channel, a store-independent Orai channel.Channels (Austin, Tex.)Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following stimulation with a calcium-mobilizing agonist there is often a distinct latency (L) preceding the onset of the first calcium spike. In the continued presence of the agonist, repetitive spikes appear separated by a variable period (P). The relationship between L and P has been investigated in an insect salivary gland responding to 5-hydroxytryptamine (5-HT). Both L and P were found to decrease as the concentration of 5-HT was increased over its physiological range of 1-10 nM. Lowering the concentration of external calcium from 1 x 10(-3) M to 1 x 10(-5) M increased both P and L. However, the effect on L was apparent only at low levels of 5-HT. Reducing the content of the internal stores by repeated stimulation in a calcium-free medium resulted in a progressive prolongation of L. On the other hand, the effect of L decreased when glands were stimulated repetitively in normal calcium-containing medium. All these results are consistent with a hypothesis that calcium plays a critical role in determining the kinetics of calcium release during both L and P. An important component seems to be the entry of external calcium, which sets the stage for calcium release by loading up the internal stores. As these stores fill up with calcium, the Ins(1,4,5)P3 receptors will initiate a calcium spike once they become sensitized to the ambient level of Ins(1,4,5)P3.
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