ArticleProceedings of the National Academy of Sciences of the United States of America1994
Long-term culture and functional characterization of follicular cells from adult normal human thyroids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 88 citations in OpenAlex.
- Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity.NPJ microgravity · 2024Article
- ZFP36L2 Role in Thyroid Functionality.International journal of molecular sciences · 2021Article
- Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines.Applied in vitro toxicology · 2021Article
- Fighting Thyroid Cancer with Microgravity Research.International journal of molecular sciences · 2019Review
- Establishment and Evaluation of a Stable Bovine Thyroid Cell Line for Investigating Foot-and-Mouth Disease Virus.Frontiers in microbiology · 2018Article
- Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.Frontiers in endocrinology · 2017Article
- Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.Oncotarget · 2014Article
- Characterization of recombinant human and bovine thyroid-stimulating hormone preparations by mass spectrometry and determination of their endotoxin content.BMC veterinary research · 2013Article
- Interaction of proteins identified in human thyroid cells.International journal of molecular sciences · 2013Article
- FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma.Endocrine-related cancer · 2012Article
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- Adipose tissue-derived stem cell in vitro differentiation in a three-dimensional dental bud structure.The American journal of pathology · 2011Article
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- Resistance to rituximab therapy and local BAFF overexpression in Sjögren's syndrome-related myoepithelial sialadenitis and low-grade parotid B-cell lymphoma.The open rheumatology journal · 2008Article
- Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.Endocrine-related cancer · 2007Article
- Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Expression of haematopoietic stem cell markers, CD133 and CD34 on human corneal keratocytes.The British journal of ophthalmology · 2007Article
- RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.Oncogene · 2005Article
- UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have obtained long-term cultures of differentiated proliferating follicular cells from normal adult human thyroid glands. In vitro growth of such human cells has been sustained by a modified F-12 medium, supplemented with bovine hypothalamus and pituitary extracts and no added thyrotropin. Cultures have been expanded, cloned, frozen, successfully retrieved, and characterized. Functional characterization of these cells shows constitutive thyroglobulin production and release and thyrotropin-dependent adenosine 3',5'-cyclic monophosphate production, the latter apparently not associated with significant increases in DNA synthesis or cell proliferation. Genetic characterization of these cells by chromosome counting showed the normal diploid chromosome number. The ability to cultivate differentiated human thyroid follicular cells in long-term culture opens possibilities for investigating the transduction pathways of thyrotropin stimulation in normal and pathological human tissues, developing clinically relevant in vitro assays, and considering cellular and molecular therapies.
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