ArticleThe Journal of cell biology1994
Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 153 citations in OpenAlex.
- The roles of cytoplasmic dynein complex in various ocular disorders.Molecular medicine (Cambridge, Mass.) · 2026Review
- Seasonal environmental fluctuations alter the transcriptome dynamics of oocytes and granulosa cells in beef cows.Journal of ovarian research · 2024Article
- The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination.Development (Cambridge, England) · 2024Article
- The dynamic duo of microtubule polymerase Mini spindles/XMAP215 and cytoplasmic dynein is essential for maintainingProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Optimal RNA binding by Egalitarian, a Dynein cargo adaptor, is critical for maintaining oocyte fate inRNA biology · 2021Article
- In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.Development (Cambridge, England) · 2021Article
- The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes duringOpen biology · 2021Article
- Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination.Molecular biology of the cell · 2021Article
- Patterning the Drosophila embryo: A paradigm for RNA-based developmental genetic regulation.Wiley interdisciplinary reviews. RNA · 2020Review
- The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor.Development (Cambridge, England) · 2019Article
- Review
- Recent advances in understanding oogenesis: interactions with the cytoskeleton, microtubule organization, and meiotic spindle assembly in oocytes.F1000Research · 2018Review
- Article
- Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development.Biology open · 2016Article
- Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways.Biology open · 2015Article
- A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.Development (Cambridge, England) · 2015Article
- asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesis.Developmental biology · 2014Article
- Dynein associates with oskar mRNPs and is required for their efficient net plus-end localization in Drosophila oocytes.PloS one · 2013Article
- Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The unidirectional movements of the microtubule-associated motors, dyneins, and kinesins, provide an important mechanism for the positioning of cellular organelles and molecules. An intriguing possibility is that this mechanism may underlie the directed transport and asymmetric positioning of morphogens that influence the development of multicellular embryos. In this report, we characterize the Drosophila gene, Dhc64C, that encodes a cytoplasmic dynein heavy chain polypeptide. The primary structure of the Drosophila cytoplasmic dynein heavy chain polypeptide has been determined by the isolation and sequence analysis of overlapping cDNA clones. Drosophila cytoplasmic dynein is highly similar in sequence and structure to cytoplasmic dynein isoforms reported for other organisms. The Dhc64C dynein transcript is differentially expressed during development with the highest levels being detected in the ovaries of adult females. Within the developing egg chambers of the ovary, the dynein gene is predominantly transcribed in the nurse cell complex. In contrast, the encoded dynein motor protein displays a striking accumulation in the single cell that will develop as the oocyte. The temporal and spatial pattern of dynein accumulation in the oocyte is remarkably similar to that of several maternal effect gene products that are essential for oocyte differentiation and axis specification. This distribution and its disruption by specific maternal effect mutations lends support to recent models suggesting that microtubule motors participate in the transport of these morphogens from the nurse cell cytoplasm to the oocyte.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.