ArticleGenetics1994
The Tc5 family of transposable elements in Caenorhabditis elegans.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Bridging the Gap between Sequence and Structure Classifications of Proteins with AlphaFold Models.Journal of molecular biology · 2024Article
- A left-handed RNA quadruplex directs gene silencing.Trends in biochemical sciences · 2024Review
- Article
- Visualization and Quantification of Transposon Activity inG3 (Bethesda, Md.) · 2019Article
- Artificial and natural RNA interactions between bacteria and C. elegans.RNA biology · 2017Review
- Forward and reverse mutagenesis in C. elegans.WormBook : the online review of C. elegans biology · 2014Review
- Whole genome resequencing reveals natural target site preferences of transposable elements in Drosophila melanogaster.PloS one · 2012Article
- Cancer models in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Testing the palindromic target site model for DNA transposon insertion using the Drosophila melanogaster P-element.Nucleic acids research · 2008Article
- Article
- Continuous exchange of sequence information between dispersed Tc1 transposons in the Caenorhabditis elegans genome.Genetics · 2003Article
- A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.Genetics · 2002Article
- Identification of 1088 new transposon insertions of Caenorhabditis elegans: a pilot study toward large-scale screens.Genetics · 2002Article
- Tc8, a Tourist-like transposon in Caenorhabditis elegans.Genetics · 2001Article
- Transposons but not retrotransposons are located preferentially in regions of high recombination rate in Caenorhabditis elegans.Genetics · 2000Article
- Tc7, a Tc1-hitch hiking transposon in Caenorhabditis elegans.Nucleic acids research · 1997Article
- Characterization of the Sol3 family of nonautonomous transposable elements in tomato and potato.Journal of molecular evolution · 1997Article
- A transposon-based strategy for sequencing repetitive DNA in eukaryotic genomes.Genome research · 1997Article
- Members of the pogo superfamily of DNA-mediated transposons in the human genome.Molecular & general genetics : MGG · 1996Article
- Identification of putative nonautonomous transposable elements associated with several transposon families in Caenorhabditis elegans.Journal of molecular evolution · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We have identified Tc5, a new family of transposable genetic elements in the nematode Caenorhabditis elegans. All wild-type varieties of C. elegans that we examined contain 4-6 copies of Tc5 per haploid genome, but we did not observe transposition or excision of Tc5 in these strains. Tc5 is active, however, in the mut-2 mutant strain TR679. Of 60 spontaneous unc-22 mutations isolated from strain TR679, three were caused by insertion of Tc5. All three Tc5-induced mutations are unstable; revertants results from precise or nearly precise excision of Tc5. Individual Tc5 elements are similar to each other in size and structure. The 3.2-kb element is bounded by inverted terminal repeats of nearly 500 bp. Eight of the ten terminal nucleotides of Tc5 are identical to the corresponding nucleotides of Tc4. Further, both elements recognize the same target site for insertion (CTNAG) and both cause duplication of the central TNA trinucleotide upon insertion. Other than these similarities to Tc4, Tc5 is unrelated to the three other transposon families (Tc1, Tc3 and Tc4) that transpose and excise at high frequency in mut-2 mutant strains. Mechanisms are discussed by which four apparently unrelated transposon families are all affected by the same mut-2 mutation.
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