ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology1994
Amplified rhinovirus colds in atopic subjects.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 100 citations in OpenAlex.
- Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1997Trial
- Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections.Journal of experimental pharmacology · 2021Review
- Interrupting the Conversation: Implications for Crosstalk Between Viral and Bacterial Infections in the Asthmatic Airway.Frontiers in allergy · 2021Review
- The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.Respiratory research · 2018Review
- Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma.PloS one · 2017Article
- Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite.Asia Pacific allergy · 2015Article
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Population-based study of the association between asthma and pneumococcal disease in children.Clinical epidemiology · 2015Article
- Article
- Rhinovirus-associated wheeze during infancy and asthma development.Current respiratory medicine reviews · 2011Article
- The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery.Medicinal research reviews · 2011Review
- Role of infection in the development and exacerbation of asthma.Expert review of respiratory medicine · 2010Review
- Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Article
- Host immune responses to rhinovirus: mechanisms in asthma.The Journal of allergy and clinical immunology · 2008Review
- Mechanisms of virus-induced asthma exacerbations: state-of-the-art. A GA2LEN and InterAirways document.Allergy · 2007Review
- An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study.Respiratory research · 2006Article
- CD8+ T cells and immunoregulatory networks in asthma.Springer seminars in immunopathology · 2004Review
- Host defense function of the airway epithelium in health and disease: clinical background.Journal of leukocyte biology · 2004Review
- An adult model of exclusive viral wheeze: inflammation in the upper and lower respiratory tracts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2003Article
- Rhinoviruses in the pathogenesis of asthma.Current allergy and asthma reports · 2003Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that atopic individuals may be predisposed to more severe rhinoviral colds coupled to a worsening of existing airway disease than those with asthma. The role of atopy and IgE levels, as well as their relationship to clinical disease expression have not been defined. We hypothesized that an allergic diathesis modulates rhinoviral colds and have initiated studies of normal, atopic and asthmatic subjects employing experimental rhinoviral infection, with measurements of symptom scores, viral shedding and cultures, albumin in nasal washes and serological responses. Twenty-two subjects (11 normal, 5 atopic, 6 atopic and asthmatic) participated and were inoculated with human rhinovirus serotype 16 (HRV 16). Measurements of neutralizing antibody and viral culture were performed at screening, pre-inoculation, during the cold and at 8-10 weeks convalescence. Daily symptoms were noted, nasal washes done, IgE measured and atopy was diagnosed by skin tests. Seventeen volunteers developed clinical colds as assessed by symptom scores, virus shedding was demonstrated (with positive culture) in all subjects and a fourfold or higher seroconversion occurred in 11/22. Neutralizing HRV antibody developed unexpectedly in 10 subjects between screening and inoculation and the presence of absence of this pre-inoculation antibody determined subsequent severity of colds in normal but not in atopic subjects. Atopic antibody positive individuals developed severe clinical colds that were independent of preinoculation antibody in contrast to normal subjects who developed mild colds in the presence of a neutralizing antibody (P = 0.01). Both atopic and normal antibody negative subjects developed severe colds.(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.