ArticleThe Journal of clinical investigation1994
Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 385 citations in OpenAlex.
- Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive.Journal of reproductive immunology · 2015Trial
- Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome.Open veterinary journal · 2024Article
- Mechanisms of Regeneration and Fibrosis in the Endometrium.Annual review of cell and developmental biology · 2023Review
- Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis.International journal of molecular sciences · 2023Article
- Expression of laminin-1 and matrix metalloproteinase-9 in benign and malignant endometrium.Turkish journal of medical sciences · 2023Article
- Altered differentiation of endometrial mesenchymal stromal fibroblasts is associated with endometriosis susceptibility.Communications biology · 2022Article
- PPARγ Agonists: Emergent Therapy in Endometriosis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation.Frontiers in physiology · 2021Article
- Curcumin and Endometriosis.International journal of molecular sciences · 2020Review
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights.International journal of molecular sciences · 2019Review
- A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid.Scientific reports · 2019Article
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review).Molecular medicine reports · 2018Review
- Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.BioMed research international · 2015Article
- Collagen type IV at the fetal-maternal interface.Placenta · 2015Article
- CXCR7 expression in nasopharyngeal carcinoma tissues correlates with disease severity.International journal of clinical and experimental medicine · 2015Article
- Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts.Journal of cellular and molecular medicine · 2013Article
- Molecular and functional aspects of menstruation in the macaque.Reviews in endocrine & metabolic disorders · 2012Review
- Steroid regulation of menstrual bleeding and endometrial repair.Reviews in endocrine & metabolic disorders · 2012Review
- Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).Fertility and sterility · 2012Article
- Pathogenesis and pathophysiology of endometriosis.Fertility and sterility · 2012Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Matrix metalloproteinases are a highly regulated family of enzymes, that together can degrade most components of the extracellular matrix. These proteins are active in normal and pathological processes involving tissue remodeling; however, their sites of synthesis and specific roles are poorly understood. Using in situ hybridization, we determined cellular distributions of matrix metalloproteinases and tissue inhibitor of metalloproteinase-1, an inhibitor of matrix metalloproteinases, in endometrium during the reproductive cycle. The mRNAs for all the metalloproteinases were detected in menstrual endometrium, but with different tissue distributions. The mRNA for matrilysin was localized to epithelium, while the others were detected in stromal cells. Only the transcripts for the 72-kD gelatinase and tissue inhibitor of metalloproteinases-1 were detected throughout the cycle. Transcripts for stromelysin-2 and the 92-kD gelatinase were only detected in late secretory and menstrual endometrium, while those for matrilysin, the 72-kD gelatinase, and stromelysin-3 were also consistently detected in proliferative endometrium. These data indicate that matrix metalloproteinases are expressed in cell-type, tissue, and reproductive cycle-specific patterns, consistent with regulation by steroid hormones, and with specific roles in the complex tissue growth and remodeling processes occurring in the endometrium during the reproductive cycle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.