ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1994
Immunohistochemical characterization of surgically removed subfoveal fibrovascular membranes.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 97 citations in OpenAlex.
- Intravitreal combination of dexamethasone sodium phosphate and bevacizumab in the treatment of exudative AMD.Scientific reports · 2015Trial
- A Novel Ocular Fibrosis Signature for AMD Using the Two-Stage Laser-Induced Subretinal Fibrosis Mouse Model.Investigative ophthalmology & visual science · 2026Article
- The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases.Investigative ophthalmology & visual science · 2025Review
- Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration.Cell reports. Medicine · 2024Article
- CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy.Advances in experimental medicine and biology · 2023Review
- Outcomes of adalimumab therapy in refractory punctate inner choroidopathy and multifocal choroiditis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- The effects of anti-VEGF and kinin BBritish journal of pharmacology · 2020Article
- Factors Affecting Compliance to Intravitreal Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.Turkish journal of ophthalmology · 2017Article
- Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn.Frontiers in pharmacology · 2016Article
- Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits.Disease models & mechanisms · 2015Article
- Article
- The role of epigenetics in age-related macular degeneration.Eye (London, England) · 2014Review
- Immunology of age-related macular degeneration.Nature reviews. Immunology · 2013Review
- Vascular adhesion protein 1 in the eye.Journal of ophthalmology · 2013Article
- Reconsidering the connection between vitamin D levels and age-related macular degeneration.Eye (London, England) · 2011Article
- MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium.Investigative ophthalmology & visual science · 2011Article
- Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes.Investigative ophthalmology & visual science · 2009Article
- Modulation of choroidal neovascularization by subretinal injection of retinal pigment epithelium and polystyrene microbeads.Molecular vision · 2009Article
- Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells.Experimental eye research · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eighteen patients with age-related macular degeneration developed subfoveal membranes that were surgically removed and submitted for histopathological examination. Immunohistochemical techniques were performed, using a panel of monoclonal antibodies recognizing retinal pigment epithelial (RPE) cells, myofibroblasts, pericytes, endothelial cells, glial cells, smooth muscle cells and various types of macrophages. The PC10 antibody to proliferating cell nuclear antigen (PCNA) was applied as a marker of proliferating cells. The specimens displayed a core of neovascular stroma surrounded by a rim of more fibrous tissue. All specimens contained abundant RPE cells that in some cases appeared to envelop part of the membrane. Most cases had basal laminar deposits and thickened basement membrane material adjacent to the RPE cells suggestive of parts of Bruch's membrane. Often this Bruchlike membrane appeared at the surgical margin, forming a surgical cleavage plane. Chronic inflammatory cells were abundant, but polymorphonuclear leukocytes were notably absent. Nearly all specimens contained myofibroblasts and various types of macrophages. The presence of myofibroblasts suggests subretinal membrane contraction, which may induce new breaks and other pathology in RPE layer and Bruch's membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.