ArticleClinical and experimental immunology1994
Possible association of CD3 and CD4 polymorphisms with insulin-dependent diabetes mellitus (IDDM).
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Link-based quantitative methods to identify differentially coexpressed genes and gene pairs.BMC bioinformatics · 2011Article
- Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.American journal of hematology · 2010Article
- Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.BMC medical genetics · 2010Article
- Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population and family studies show that predisposition to type I diabetes (IDDM) is multifactorial, and that polymorphisms in the MHC region contribute substantially to the susceptibility to IDDM. In the present study the association of polymorphisms in the CD4 and the delta subunit of CD3 with IDDM were examined in a Belgian population. We observed that the frequency of the CD A4/A4 genotype and of the CD3 91 allele were significantly increased P = 0.0077) and decreased (P = 3.8 x 10(-5), respectively, in IDDM compared with controls. These results therefore suggest that CD4, CD3 or neighbouring genes might contribute to IDDM susceptibility. These results are, however, preliminary and cannot be considered as established until re-tested in a new population.
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