ArticleClinical and experimental immunology1994
Serum antibody responses by male and female C57Bl/6 mice infected with Giardia muris.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Role of anti-Giardia recombinant cyst wall protein IgG polyclonal antibodies in diagnosis and protection.AMB Express · 2022Article
- Expression of Sex Hormone Receptor and Immune Response Genes in Peripheral Blood Mononuclear Cells During the Menstrual Cycle.Frontiers in endocrinology · 2021Article
- Article
- RORγtScientific reports · 2019Article
- Cerebrospinal Nematodiasis in 20 Camelids.Journal of veterinary internal medicine · 2016Article
- Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha.Infection and immunity · 2014Article
- Estradiol downregulates NF-κb translocation by Ikbkg transcriptional repression in dendritic cells.Genes and immunity · 2013Article
- Article
- Effect of sex steroids on Babesia microti infection in mice.The American journal of tropical medicine and hygiene · 2013Article
- Central importance of immunoglobulin A in host defense against Giardia spp.Infection and immunity · 2002Article
- Tularemia vaccine development: paralysis or progress?Vaccine (Auckland, N.Z.)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared the levels of serum antibodies in male and female C57Bl/6 mice during the primary and after challenge infection with Giardia muris. Male mice began passing cysts in their faeces earlier than females, and were shedding cysts for over 60 days, while females stopped shedding cysts by day 20 after infection. In both males and females there were significant increases in parasite-specific IgM 10 and 20 days after infection. No differences in parasite-specific serum IgA were observed until 40 days after infection. Parasite-specific IgG (whole) levels were elevated on days 20 and 40 in females, while males showed no significant increases. In addition, females had a much stronger IgG2b and IgG3 response than males. After challenge with either cysts or soluble parasite protein only the females had significant increases in specific anti-parasite IgG2b. Our data show differential ability of males and females to control the infection with G. muris is paralleled by a difference in the anti-parasite serum IgG response of the mice.
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Registered trials
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