ArticleCurrent genetics1994
PET112, a Saccharomyces cerevisiae nuclear gene required to maintain rho+ mitochondrial DNA.
Article in Current genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Mitochondrial Aminoacyl-tRNA Synthetase and Disease: The Yeast Contribution for Functional Analysis of Novel Variants.International journal of molecular sciences · 2021Review
- Pathogenic variants in glutamyl-tRNANature communications · 2018Article
- OsGatB, the Subunit of tRNA-Dependent Amidotransferase, Is Required for Primary Root Development in Rice.Frontiers in plant science · 2016Article
- Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase.The Journal of biological chemistry · 2011Article
- Biogenesis of glutaminyl-mt tRNAGln in human mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS.Genes & development · 2009Article
- Import of tRNAs and aminoacyl-tRNA synthetases into mitochondria.Current genetics · 2009Review
- Amino acid modifications on tRNA.Acta biochimica et biophysica Sinica · 2008Review
- Dual-targeted tRNA-dependent amidotransferase ensures both mitochondrial and chloroplastic Gln-tRNAGln synthesis in plants.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- From one amino acid to another: tRNA-dependent amino acid biosynthesis.Nucleic acids research · 2008Review
- On the evolution of the tRNA-dependent amidotransferases, GatCAB and GatDE.Journal of molecular biology · 2008Article
- Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion.Genes & development · 2005Article
- Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene.Journal of bacteriology · 1997Article
- The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA.The Journal of cell biology · 1996Article
- Molecular characterization of the BRO beta-lactamase of Moraxella (Branhamella) catarrhalis.Antimicrobial agents and chemotherapy · 1996Article
- Protein synthesis in mitochondria.Molecular biology reports · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The nuclear gene PET112 was originally identified by a mutation (pet112-1) that specifically blocked accumulation of cytochrome c oxidase subunit II. The mutation causes a post-transcriptional defect since the level of COX2 mRNA in the mutant is the same as in the wild-type. However, PET112 does not have a function similar to that of PET111, a COX2 mRNA-specific translational activator: while pet111 mutations are suppressed by chimeric COX2 mRNAs bearing 5' leaders of other mitochondrial mRNAs, pet112-1 is not. The PET112 gene was isolated and shown to code a protein of 541 residues (62 kDa) with no significant homology to known amino-acid sequences. By hybridization to defined genomic clones the gene was mapped to chromosome II between cdc25 and ils1. Disruption of the PET112 open reading frame destabilized the mitochondrial genome, causing cells to become rho-. This finding suggests that PET112 has an important general function in mitochondrial gene expression, probably in translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.