ArticleProceedings of the National Academy of Sciences of the United States of America1994
X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 87 citations in OpenAlex.
- Silver(I)-NHC Complexes as Dual-Action Agents Against PathogenicInternational journal of molecular sciences · 2025Article
- Structure of the Monkeypox virus profilin-like protein A42R reveals potential functional differences from cellular profilins.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Taro raphide-associated proteins: Allergens and crystal growth.Plant direct · 2022Article
- A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization.Microbes and infection · 2014Article
- Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I.PloS one · 2014Article
- Zm908p11, encoded by a short open reading frame (sORF) gene, functions in pollen tube growth as a profilin ligand in maize.Journal of experimental botany · 2013Article
- Article
- Characterization of profilin polymorphism in pollen with a focus on multifunctionality.PloS one · 2012Article
- Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11.Journal of molecular biology · 2010Article
- Structure and functions of profilins.Biophysical reviews · 2009Review
- Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.BMC cell biology · 2009Article
- The effects of ADF/cofilin and profilin on the conformation of the ATP-binding cleft of monomeric actin.Biophysical journal · 2009Article
- Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.Cell motility and the cytoskeleton · 2006Article
- Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site.BMC biochemistry · 2002Article
- Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast.Molecular biology of the cell · 2001Article
- Protein backbone angle restraints from searching a database for chemical shift and sequence homology.Journal of biomolecular NMR · 1999Article
- The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing.The Journal of experimental medicine · 1998Article
- The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau.Biophysical journal · 1997Article
- Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.The EMBO journal · 1996Article
- Refined solution structure of human profilin I.Protein science : a publication of the Protein Society · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We determined the structures of Acanthamoeba profilin I and profilin II by x-ray crystallography at resolutions of 2.0 and 2.8 A, respectively. The polypeptide folds and the actin-binding surfaces of the amoeba profilins are very similar to those of bovine and human profilins. The electrostatic potential surfaces of the two Acanthamoeba isoforms differ. Two areas of high positive potential on the surface of profilin II are candidate binding sites for phosphatidylinositol phosphates. The proximity of these sites to the actin binding site provides an explanation for the competition between actin and lipids for binding profilin.
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