ArticleProceedings of the National Academy of Sciences of the United States of America1994
cAMP-dependent phosphorylation of Aplysia twitchin may mediate modulation of muscle contractions by neuropeptide cotransmitters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae.Functional & integrative genomics · 2022Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.Scientific reports · 2016Article
- Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.Molecular biology of the cell · 2015Article
- A force-activated kinase in a catch smooth muscle.Journal of muscle research and cell motility · 2011Article
- Mechanism of catch force: tethering of thick and thin filaments by twitchin.Journal of biomedicine & biotechnology · 2010Article
- Gene expression analyses of essential catch factors in the smooth and striated adductor muscles of larval, juvenile and adult great scallop (Pecten maximus).Journal of muscle research and cell motility · 2009Article
- Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.Biophysical journal · 2008Article
- Temperature compensation of neuromuscular modulation in aplysia.Journal of neurophysiology · 2005Article
- Twitchin purified from molluscan catch muscles regulates interactions between actin and myosin filaments at rest in a phosphorylation-dependent manner.Journal of muscle research and cell motility · 2005Article
- Titin/connectin-related proteins in C. elegans: a review and new findings.Journal of muscle research and cell motility · 2005Review
- Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice.Molecular and cellular biology · 2002Article
- An in vitro assay reveals essential protein components for the "catch" state of invertebrate smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics.Journal of muscle research and cell motility · 1999Article
- Ca2+-dependent muscle dysfunction caused by mutation of the Caenorhabditis elegans troponin T-1 gene.The Journal of cell biology · 1998Article
- Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Phosphorylation of a high molecular weight (approximately 600 kDa) protein regulates catch in invertebrate smooth muscle.Journal of muscle research and cell motility · 1997Article
- Serotonin and the small cardioactive peptides differentially modulate two motor neurons that innervate the same muscle fibers in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Costorage and corelease of modulatory peptide cotransmitters with partially antagonistic actions on the accessory radula closer muscle of Aplysia californica.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Developmental genetic analysis of troponin T mutations in striated and nonstriated muscle cells of Caenorhabditis elegans.The Journal of cell biology · 1996Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Acting through a cAMP-cAMP-dependent protein kinase (cAPK) cascade, members of two neuropeptide families, the small cardioactive peptides and myomodulins, modulate contraction amplitude and relaxation rate in the accessory radula closer (ARC) muscle of the marine mollusc Aplysia californica. An approximately 750-kDa phosphoprotein was identified in the ARC muscle as the major substrate for cAPK activated either by application of neuropeptides or by peptides released by motorneuron stimulation at physiological frequencies. Immunoblot and immunoelectron microscopy experiments revealed the widespread presence of this protein in Aplysia muscles and its colocalization with contractile filaments in the ARC muscle. Sequence analysis of proteolytic peptide fragments derived from the protein indicated that it is structurally related to the muscle protein twitchin. Finally, the level of neuropeptide-induced phosphorylation of the protein correlated well with peptidergic modulation of the relaxation rate of the muscle. We propose that twitchin in Aplysia, and perhaps in other species, may mediate the modulation of the relaxation rate of muscle contractions.
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