ArticleNucleic acids research1994
Characterization of four human YAC libraries for clone size, chimerism and X chromosome sequence representation.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Cost-effective high-throughput single-haplotype iterative mapping and sequencing for complex genomic structures.Nature protocols · 2018Article
- Recovery and potential utility of YACs as circular YACs/BACs.Nucleic acids research · 2000Article
- Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Linkage disequilibrium and physical mapping of X-linked juvenile retinoschisis.American journal of human genetics · 1997Article
- Fine mapping of the EDA gene: a translocation breakpoint is associated with a CpG island that is transcribed.American journal of human genetics · 1996Article
- Construction of a YAC contig and an STS map spanning 3.6 megabase pairs in Xp22.1.Human genetics · 1996Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Four collections of human X-specific YACs, derived from human cells containing supernumerary X chromosomes or from somatic cell hybrids containing only X human DNA were characterized. In each collection, 80-85% of YAC strains contained a single X YAC. Five thousand YACs from the various libraries were sized, and cocloning was assessed in subsets by the fraction of YAC insert-ends with non-X sequences. Cocloning was substantial, ranging up to 50% for different collections; and in agreement with previous indications, in all libraries the larger the YACs, the higher the level of cocloning. In libraries made from human-hamster hybrid cells, expected numbers of clones were recovered by STS-based screening; but unexpectedly, the two collections from cells with 4 or 5 X chromosomes yielded numbers of YACs corresponding to an apparent content of only about two X equivalents. Thus it is possible that the DNA of inactive X chromosomes is poorly cloned into YACs, speculatively perhaps because of its specialized chromatin structure.
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