ArticleNucleic acids research1994
Stereochemical basis of DNA recognition by Zn fingers.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Computational Modeling Approach in Probing the Effects of Cytosine Methylation on the Transcription Factor Binding to DNA.Current topics in medicinal chemistry · 2017Article
- Bioinformatic analysis of the protein/DNA interface.Nucleic acids research · 2014Article
- Protein-DNA binding: complexities and multi-protein codes.Nucleic acids research · 2014Review
- Loss of the insulator protein CTCF during nematode evolution.BMC molecular biology · 2009Article
- Biz1, a zinc finger protein required for plant invasion by Ustilago maydis, regulates the levels of a mitotic cyclin.The Plant cell · 2006Article
- Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein.BMC bioinformatics · 2005Article
- Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.Molecular and cellular biology · 2005Article
- Cloning and characterization of cDNAs encoding putative CTCFs in the mosquitoes, Aedes aegypti and Anopheles gambiae.BMC molecular biology · 2005Article
- Ab initio prediction of transcription factor targets using structural knowledge.PLoS computational biology · 2005Article
- CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator.EMBO reports · 2005Article
- Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF.Nucleic acids research · 2004Article
- COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.The Biochemical journal · 2002Article
- All in the family: the BTB/POZ, KRAB, and SCAN domains.Molecular and cellular biology · 2001Review
- An overview of the structures of protein-DNA complexes.Genome biology · 2000Review
- Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Major versus minor groove DNA binding of a bisarginylporphyrin hybrid molecule: a molecular mechanics investigation.Journal of computer-aided molecular design · 1999Article
- Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product.Nucleic acids research · 1998Article
- NMR chemical shift perturbation mapping of DNA binding by a zinc-finger domain from the yeast transcription factor ADR1.Protein science : a publication of the Protein Society · 1997Article
- Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains.Molecular and cellular biology · 1997Article
- Binding of YY1 to a site overlapping a weak TATA box is essential for transcription from the uteroglobin promoter in endometrial cells.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA-recognition rules for Zn fingers are discussed in terms of crystal structures. The rules can explain the DNA-binding characteristics of a number of Zn finger proteins for which there are no crystal structures. The rules have two parts: chemical rules, which list the possible pairings between the 4 DNA bases and the 20 amino acid residues, and stereochemical rules, which describe the specific base positions contacted by several amino acid positions in the Zn finger. It is discussed that to maintain the correct binding geometry, in which the N-terminus of the recognition helix is closer to the DNA than the C-terminus, the residues facing the DNA on the helix must be larger near the C-terminus, and that two different types of fingers (A and B) bind to DNA in distinctly different ways and cover different numbers of base pairs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.