ArticleMolecular & general genetics : MGG1994
KIN17, a mouse nuclear protein, binds to bent DNA fragments that are found at illegitimate recombination junctions in mammalian cells.
Article in Molecular & general genetics : MGG, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop.Signal transduction and targeted therapy · 2025Article
- KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma.Human cell · 2024Article
- Roles and regulatory mechanisms of KIN17 in cancers (Review).Oncology letters · 2023Review
- A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.PLoS genetics · 2022Article
- KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer.Thoracic cancer · 2021Article
- Biophysical characterization and molecular phylogeny of human KIN protein.European biophysics journal : EBJ · 2019Article
- Comparative genomics of Clavibacter michiganensis subspecies, pathogens of important agricultural crops.PloS one · 2017Article
- The kin17 Protein in Murine Melanoma Cells.International journal of molecular sciences · 2015Article
- Genome-wide analysis of transcription factor binding sites and their characteristic DNA structures.BMC genomics · 2015Article
- Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cellsOncology letters · 2014Article
- The Arabidopsis KIN17 and its homolog KLP mediate different aspects of plant growth and development.Plant signaling & behavior · 2014Article
- Gene expression divergence is coupled to evolution of DNA structure in coding regions.PLoS computational biology · 2011Article
- Article
- Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.Protein science : a publication of the Protein Society · 2007Article
- Involvement of DNA curvature in intergenic regions of prokaryotes.Nucleic acids research · 2006Article
- The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins.Molecular and cellular biology · 2005Article
- Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.Nucleic acids research · 2003Article
- Fis is required for illegitimate recombination during formation of lambda bio transducing phage.Journal of bacteriology · 1997Article
- Role of enzymes of homologous recombination in illegitimate plasmid recombination in Bacillus subtilis.Journal of bacteriology · 1997Article
- The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA.The Biochemical journal · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Illegitimate recombination is the dominant mechanism of recombination in mammalian somatic cells. It is responsible for most genome rearrangements such as translocations, deletions and integrations. Little is known as yet about the mechanism of illegitimate recombination and the enzymes involved. Recently, it has been shown that intrinsically bent DNA, also known as curved DNA, is present at chromosomal sites of illegitimate recombination events. Here we report that KIN17, a new mouse nuclear protein, binds to the curved DNA fragments found at illegitimate recombination sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.