ArticleJournal of clinical microbiology1994
Detection of cytomegalovirus DNA in sera of liver transplant recipients.
Article in Journal of clinical microbiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001477 (Monitoring Patients for Developing Communicable and Opportunistic Infections and for Responding to Therapy), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Monitoring Patients for Developing Communicable and Opportunistic Infections and for Responding to Therapy
Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Evaluation of the AMPLICOR CMV test for direct detection of cytomegalovirus in plasma specimens.Journal of clinical microbiology · 1997Trial
- PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection.Journal of clinical microbiology · 1995Trial
- Biographical Feature: Robin Patel, M.D.(C.M.), D(ABMM), F(AAM), FIDSA, FACP.Journal of clinical microbiology · 2020Article
- Detection of human cytomegalovirus DNA in various blood components after liver transplantation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Human herpesvirus 8 load in matched serum and plasma samples of patients with AIDS-associated Kaposi's sarcoma.Journal of clinical microbiology · 2003Article
- Human cytomegalovirus DNA in plasma and serum specimens of renal transplant recipients is highly fragmented.Journal of clinical microbiology · 2002Article
- Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients.Journal of clinical microbiology · 2002Article
- False-positive results of plasma PCR for cytomegalovirus DNA due to delayed sample preparation.Journal of clinical microbiology · 2000Article
- Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver transplantation.Journal of clinical microbiology · 2000Article
- New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients.Clinical microbiology reviews · 2000Review
- Use of molecular assays in diagnosis and monitoring of cytomegalovirus disease following renal transplantation.Journal of clinical microbiology · 1999Article
- Evaluation of PCR primers for cytomegalovirus detection.Journal of clinical microbiology · 1999Article
- A highly sensitive assay for detection and quantitation of human cytomegalovirus DNA in serum and plasma by PCR and electrochemiluminescence.Journal of clinical microbiology · 1999Article
- Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients.Journal of clinical pathology · 1998Article
- Evaluation of the murex hybrid capture cytomegalovirus DNA assay versus plasma PCR and shell vial assay for diagnosis of human cytomegalovirus viremia in immunocompromised patients.Journal of clinical microbiology · 1998Article
- Quantitation of cytomegalovirus: methodologic aspects and clinical applications.Clinical microbiology reviews · 1998Review
- Utility of major leukocyte subpopulations for monitoring secondary cytomegalovirus infections in renal-allograft recipients by PCR.Journal of clinical microbiology · 1998Article
- Evaluation of PCR primers for early diagnosis of cytomegalovirus infection following liver transplantation.Journal of clinical microbiology · 1998Article
- Review
- Infections in solid-organ transplant recipients.Clinical microbiology reviews · 1997Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We prospectively studied the utility of the amplification of cytomegalovirus (CMV) DNA in the sera of liver transplant recipients in order to predict symptomatic CMV infection, thus enabling preemptive therapy with antiviral agents. Serum samples obtained at biweekly intervals from 20 sequential liver transplant recipients for at least 8 weeks following transplantation were tested by the PCR amplification procedure. Results were correlated with blood and urine cultures, histopathological findings from infected organs, and clinical manifestations. Six patients (30%) developed symptomatic CMV infection; in five (83%) of these patients, CMV DNA was detected prior to symptomatic CMV infection, and in one (17%) of these patients, CMV DNA was detected at the time of symptomatic CMV infection. CMV DNA was detected a mean of 13 days (range, 0 to 23 days) prior to the onset of symptomatic CMV infection. In addition, CMV DNA was detected in the sera of four of five patients with asymptomatic viremia and two patients with asymptomatic viruria. Lastly, the PCR was negative for sera from seven patients with no evidence of CMV infection. We found that PCR was able to detect the presence of CMV DNA in the sera of liver transplant recipients at a sensitivity of 92% and a specificity of 100% for CMV infection, while the sensitivity and specificity for symptomatic infection were 100 and 57%, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.