ReviewJournal of bioenergetics and biomembranes1994
Molecular basis of mitochondrial DNA disease.
Review in Journal of bioenergetics and biomembranes, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 147 citations in OpenAlex.
- Proteomic and Metabolomic Profiling Reveals Alterations in Boar X and Y Sperm.Animals : an open access journal from MDPI · 2024Article
- Optical redox imaging of ANT1-deficient muscles.Journal of innovative optical health sciences · 2024Article
- Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment.Acta neuropathologica communications · 2023Review
- Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia.Scientific reports · 2015Article
- Lack of association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and keratoconus in a Polish subpopulation.Archives of medical science : AMS · 2015Article
- Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.Neurobiology of aging · 2014Article
- The role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to tyrosine kinase inhibitors.International journal of molecular sciences · 2013Article
- Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.Journal of Alzheimer's disease : JAD · 2012Article
- Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease.Journal of hepatology · 2011Article
- [Hereditary optic atrophies].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2009Article
- Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults.Biochimica et biophysica acta · 2009Article
- Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells.The Journal of biological chemistry · 2008Article
- Molecular evolution at the cytochrome oxidase subunit 2 gene among divergent populations of the intertidal copepod, Tigriopus californicus.Journal of molecular evolution · 2006Article
- Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.Journal of human genetics · 2006Article
- Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid.BMC cancer · 2004Article
- Mitochondrial diabetes mellitus.Journal of endocrinological investigation · 2002Review
- A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13.American journal of human genetics · 2001Article
- Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts.The Journal of clinical investigation · 1999Article
- Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA.The Journal of cell biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondrial ATP production via oxidative phosphorylation (OXPHOS) is essential for normal function and maintenance of human organ systems. Since OXPHOS biogenesis depends on both nuclear- and mitochondrial-encoded gene products, mutations in both genomes can result in impaired electron transport and ATP synthesis, thus causing tissue dysfunction and, ultimately, human disease. Over 30 mitochondrial DNA (mtDNA) point mutations and over 100 mtDNA rearrangements have now been identified as etiological factors in human disease. Because of the unique characteristics of mtDNA genetics, genotype/phenotype associations are often complex and disease expression can be influenced by a number of factors, including the presence of nuclear modifying or susceptibility alleles. Accordingly, these mutations result in an extraordinarily broad spectrum of clinical phenotypes ranging from systemic, lethal pediatric disease to late-onset, tissue-specific neurodegenerative disorders. In spite of its complexity, an understanding of the molecular basis of mitochondrial DNA disease will be essential as the first step toward rationale and permanent curative therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.