ArticleEuropean journal of applied physiology and occupational physiology1994
Effects of glucose ingestion or glucose infusion on fuel substrate kinetics during prolonged exercise.
Article in European journal of applied physiology and occupational physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Carbohydrate dose influences liver and muscle glycogen oxidation and performance during prolonged exercise.Physiological reports · 2018Trial
- Fuel kinetics during intense running and cycling when fed carbohydrate.European journal of applied physiology and occupational physiology · 1996Trial
- Enhanced endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet.European journal of applied physiology and occupational physiology · 1994Trial
- Fuelled or Fooled? Examining the Evidence and Mechanisms Behind Ultra-High Carbohydrate Intake in Endurance Athletes.Sports medicine (Auckland, N.Z.) · 2026Review
- Does a low-carbohydrate diet impede endurance sports performance? No.The American journal of clinical nutrition · 2026Article
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews · 2026Review
- Are very high rates of exogenous carbohydrate ingestion (>90 g/hr) sufficient or indeed necessary to run a sub-2hr marathon? An analysis of the model predictions of Lukasiewicz and colleagues.Frontiers in nutrition · 2024Article
- New Horizons in Carbohydrate Research and Application for Endurance Athletes.Sports medicine (Auckland, N.Z.) · 2022Review
- What Is the Evidence That Dietary Macronutrient Composition Influences Exercise Performance? A Narrative Review.Nutrients · 2022Review
- Carbohydrate Dependence During Prolonged, Intense Endurance Exercise.Sports medicine (Auckland, N.Z.) · 2015Review
- Fructose-Glucose Composite Carbohydrates and Endurance Performance: Critical Review and Future Perspectives.Sports medicine (Auckland, N.Z.) · 2015Review
- Glucose kinetics during prolonged exercise in highly trained human subjects: effect of glucose ingestion.The Journal of physiology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine if bypassing both intestinal absorption and hepatic glucose uptake by intravenous glucose infusion might increase the rate of muscle glucose oxidation above 1 g.min-1, ten endurance-trained subjects were studied during 125 min of cycling at 70% of peak oxygen uptake (VO2peak). During exercise the subjects ingested either a 15 g.100 ml-1 U-14C labelled glucose solution or H2O labelled with a U-14C glucose tracer for the determination of the rates of plasma glucose oxidation (Rox) and exogenous carbohydrate (CHO) oxidation from plasma 14C glucose and 14CO2 specific activities, and respiratory gas exchange. Simultaneously, 2-3H glucose was infused at a constant rate to measure glucose turnover, while unlabelled glucose (25% dextrose) was infused into those subjects not ingesting glucose to maintain plasma glucose concentration at 5 mmol.l-1. Despite similar plasma glucose concentrations [ingestion 5.3 (SEM 0.13) mmol.l-1; infusion 5.0 (0.09) mmol.l-1], compared to glucose infusion, CHO ingestion significantly increased plasma insulin concentrations [12.9 (1.0) vs 4.8 (0.5) mU.l-1; P < 0.05], raised total Rox values [9.5 (1.2) vs 6.2 (0.7) mmol.125 min-1 kg fat free mass-1 (FFM); P < 0.05] and rates of CHO oxidation [37.2 (2.8) vs 24.1 (3.9) mmol.125 min-1 kg FFM-1; P < 0.05]. An increased reliance on CHO metabolism with CHO ingestion was associated with a decrease in fat oxidation. Whereas the contribution from fat oxidation to energy production increased to 51 (10)% with glucose infusion, it only reached 18 (4)% with glucose ingestion (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.