ArticleThe EMBO journal1994
Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 132 citations in OpenAlex.
- Mechanometabolism: recent findings on the intersection of cell adhesion, cell migration, and metabolism.American journal of physiology. Cell physiology · 2025Review
- Investigating host dependence of xylose utilization in recombinant Saccharomyces cerevisiae strains using RNA-seq analysis.Biotechnology for biofuels · 2013Article
- Article
- Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen.Cellular microbiology · 2012Article
- The resistance of the yeast Saccharomyces cerevisiae to the biocide polyhexamethylene biguanide: involvement of cell wall integrity pathway and emerging role for YAP1.BMC molecular biology · 2011Article
- Glucose promotes stress resistance in the fungal pathogen Candida albicans.Molecular biology of the cell · 2009Article
- An Ustilago maydis gene involved in H2O2 detoxification is required for virulence.The Plant cell · 2007Article
- Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea.Molecular genetics and genomics : MGG · 2006Article
- The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.Molecular genetics and genomics : MGG · 2004Article
- KNQ1, a Kluyveromyces lactis gene encoding a drug efflux permease.Current genetics · 2004Article
- The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.Eukaryotic cell · 2003Article
- Osmotic stress signaling and osmoadaptation in yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- The yeast ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response.Molecular and cellular biology · 1999Article
- What sets the TonE during osmotic stress?Proceedings of the National Academy of Sciences of the United States of America · 1999Review
- Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces.Journal of bacteriology · 1999Article
- Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor.The EMBO journal · 1998Article
- MAP kinase pathways in the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Article
- Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae.Journal of bacteriology · 1998Article
- Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response.Journal of bacteriology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the YAP1 transcriptional activator renders yeast cells resistant to multiple metabolic inhibitors. In an effort to identify other gene products required for this phenotype we have isolated genomic mutations which neutralize this effect. One such mutation was further characterized and the affected gene was shown to be identical to TPS2 which encodes trehalose phosphate phosphatase, an enzyme catalysing the second step in trehalose biosynthesis. We have analysed the transcriptional regulation of the TPS2 gene and have shown that its transcription is induced by a variety of stressful conditions caused by metabolic inhibitors, osmotic shock and heat shock. This transcriptional activation is mediated by multiple stress promoter elements (C4T) and requires the function of Yap1p as well as reduced activity of the cAMP-regulated protein kinase. Using an appropriate reporter gene we have shown that Yap1p is generally required for transcriptional regulation through the C4T stress element. These results show that the YAP1 protein has a pivotal role in the metabolic stress response and the acquisition of stress tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.