Evidence map›Paper›PMID 8075851›Full record

ArticleBritish journal of pharmacology1994

Biological actions of purines on rat megakaryocytes: potentiation by adenine of the purinoceptor-operated cytoplasmic Ca2+ oscillation.

C Uneyama, H Uneyama, M Takahashi, N Akaike

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

C UneyamaDivision of Pathology, National Institute of Health Sciences, Tokyo, Japan.
H Uneyama
M Takahashi
N Akaike
National Institute of Infectious Diseases · JPKyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have found that adenine enhanced the purinoceptor-operated cytoplasmic Ca2+ oscillation in rat megakaryocytes at submillimolar concentrations. Guanine and other nucleic acid bases had no effect on this system. Adenine enhanced the reaction intensity but had no effect on the threshold concentration of ATP to evoke the oscillation.

Indexed as

AdenineAdenosine TriphosphateAnimalsCalciumCytoplasmDrug SynergismElectrophysiologyGuanineIsoquinolinesMegakaryocytesPotassium ChannelsProtein Kinase CPurinesRatsReceptors, PurinergicAdenineAdenosine TriphosphateCalciumGuanineIsoquinolinesN-(2-(methylamino)ethyl)-5-isoquinolinesulfonamidePotassium ChannelsProtein Kinase CPurinesReceptors, Purinergic

Identifiers

PMID8075851
PMCPMC1910359
OpenAlexW2075995624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.