ArticleBritish journal of pharmacology1994
Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells.
Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Fluid Shear Stress Regulates Osteogenic Differentiation via AnnexinA6-Mediated Autophagy in MC3T3-E1 Cells.International journal of molecular sciences · 2022Article
- Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats.The Journal of veterinary medical science · 2022Article
- ER-luminal [CaeLife · 2020Article
- Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis.Journal of translational medicine · 2016Review
- Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation.Journal of cancer research and clinical oncology · 2009Article
- The annexins.Genome biology · 2004Review
- Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937.British journal of pharmacology · 2003Article
- Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma.World journal of gastroenterology · 2003Article
- Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes.Mediators of inflammation · 2000Article
- Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.British journal of pharmacology · 1999Article
- Annexins I and II bind to lipid A: a possible role in the inhibition of endotoxins.The Biochemical journal · 1998Article
- Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation.British journal of pharmacology · 1996Article
- Evidence for specific annexin I-binding proteins on human monocytes.The Biochemical journal · 1996Article
- Translocation of lipocortin (annexin) 1 to the membrane of U937 cells induced by phorbol ester, but not by dexamethasone.British journal of pharmacology · 1996Article
- Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1.British journal of pharmacology · 1996Article
- Dexamethasone induces an increase in intracellular and membrane-associated lipocortin-1 (annexin-1) in rat astrocyte primary cultures.Cellular and molecular neurobiology · 1995Article
- Effect of dexamethasone on carrageenin-induced inflammation in the lung.Mediators of inflammation · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipocortin (annexin) 1 is a putative mediator of the inflammatory effects of glucocorticoids. By flow cytometric analysis (FACS) we have studied the effect of dexamethasone on the cellular localization of lipocortin 1. U-937 cells were incubated with or without 10 nM phorbol 12-myristate 13-acetate (PMA) to induce cell differentiation. Then 1 microM dexamethasone was added and incubation carried out for increasing times (1-24 h). Dexamethasone caused a time-dependent biphasic translocation of lipocortin 1 from the intracellular compartment to the cell membrane with maximal membrane expression at 4 and 24 h. In differentiated U-937 cells the steroid-induced membrane accumulation of lipocortin 1 was significantly higher than that of undifferentiated cells. The accumulation of the protein in the cell membrane may precede its release which is stimulated by dexamethasone in differentiated U-937 cells. Since extracellular lipocortin 1 has anti-inflammatory properties the modulation of the translocation/secretion process of the protein by glucocorticoids may be part of their mechanism of action.
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