ArticleBiophysical journal1994
Local measurements of viscoelastic moduli of entangled actin networks using an oscillating magnetic bead micro-rheometer.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Developmentally programmed changes in cytoplasmic mechanics revealed by active microrheology inbioRxiv : the preprint server for biology · 2026Article
- Mucoactive Agents in Muco-Obstructive Lung Diseases: A Critical Reappraisal of Pharmacological Effects and Clinical Outcomes.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Microrheology: From Video Microscopy to Optical Tweezers.Micromachines · 2025Review
- Probabilistic analysis of spatial viscoelastic cues in 3D cell culture using magnetic microrheometry.Biophysical journal · 2025Article
- Analytical methods in studying cell force sensing: principles, current technologies and perspectives.Regenerative biomaterials · 2025Review
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells.JCI insight · 2024Article
- Viscoelasticity of diverse biological samples quantified by Acoustic Force Microrheology (AFMR).Communications biology · 2024Article
- Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelope wrinkles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Determining Thermodynamic and Material Properties of Biomolecular Condensates by Confocal Microscopy and Optical Tweezers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Biophysical Approaches for Applying and Measuring Biological Forces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Simulations of dynamically cross-linked actin networks: Morphology, rheology, and hydrodynamic interactions.PLoS computational biology · 2021Article
- Shear relaxation governs fusion dynamics of biomolecular condensates.Nature communications · 2021Article
- Multi-oscillation microrheologyLab on a chip · 2021Article
- Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy.Nature protocols · 2021Article
- Cancer cells display increased migration and deformability in pace with metastatic progression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Double power-law viscoelastic relaxation of living cells encodes motility trends.Scientific reports · 2020Article
- Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques.Respiratory research · 2019Review
- Role of a Kinesin Motor in Cancer Cell Mechanics.Nano letters · 2019Article
- From isolated structures to continuous networks: A categorization of cytoskeleton-based motile engineered biological microstructures.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
1 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
A magnetically driven bead micro-rheometer for local quantitative measurements of the viscoelastic moduli in soft macromolecular networks such as an entangled F-actin solution is described. The viscoelastic response of paramagnetic latex beads to external magnetic forces is analyzed by optical particle tracking and fast image processing. Several modes of operation are possible, including analysis of bead motion after pulse-like or oscillatory excitations, or after application of a constant force. The frequency dependencies of the storage modulus, G'(omega), and the loss modulus, G''(omega), were measured for frequencies from 10(-1) Hz to 5 Hz. For low actin concentrations (mesh sizes epsilon > 0.1 micron) we found that both G'(omega) and G''(omega) scale with omega 1/2. This scaling law and the absolute values of G' and G'' agree with conventional rheological measurements, demonstrating that the magnetic bead micro-rheometer allows quantitative measurements of the viscoelastic moduli. Local variations of the viscoelastic moduli (and thus of the network density and mesh size) can be probed in several ways: 1) by measurement of G' and G'' at different sites within the network; 2) by the simultaneous analysis of several embedded beads; and 3) by evaluation of the bead trajectories over macroscopic distances. The latter mode yields absolute values and local fluctuations of the apparent viscosity eta(x) of the network.
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