ArticleParasitology research1994
Role of surface components in the process of interaction of Giardia duodenalis with epithelial cells in vitro.
Article in Parasitology research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 23 citations in OpenAlex.
- The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment.PLoS pathogens · 2022Article
- Excreted/secreted glycoproteins of G. intestinalis play an essential role in the antibody response.Parasitology research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monosaccharides, lectins, periodate, trypsin and neuraminidase were used to analyse the process of adhesion of Giardia duodenalis trophozoites to IEC cells, an intestinal epithelial cell line. Addition of N-acetyl-glucosamine, N-acetyl-galactosamine, galactose and fucose to the interaction medium inhibited attachment of the parasites to the epithelial cells. Experiments in which the parasites or epithelial cells were treated before interaction showed that these monosaccharides interfered with both cell surfaces. Trypsin-sensitive, but not neuraminidase-sensitive, groups exposed on the cell surface are important for the parasite-epithelial cell association. Fluorescein isothiocyanate (FITC)- or colloidal gold-labeled lectins were used to analyse the distribution of carbohydrates on the surface of G. duodenalis and epithelial cells. It is important to stress here the presence of fucose on the parasite surface. Treatment of the cells with lectins was also used to analyse the role of carbohydrate-containing macromolecules in the parasite-cell interaction.
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Registered trials
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