ArticlePflugers Archiv : European journal of physiology1994
Evidence for two types of potassium current in rat choroid plexus epithelial cells.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Pathological mutation L241P in Kir7.1 channel inhibits its activity in the choroid plexus epithelium and decreases cerebrospinal fluid KJournal of physiology and biochemistry · 2026Article
- Mechanisms of cerebrospinal fluid secretion by the choroid plexus epithelium: Application to various intracranial pathologies.Clinical anatomy (New York, N.Y.) · 2025Review
- Review
- Choroid plexus and the blood-cerebrospinal fluid barrier in disease.Fluids and barriers of the CNS · 2020Review
- Tissue Distribution of Kir7.1 Inwardly Rectifying KFrontiers in physiology · 2018Article
- The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.Physiological reports · 2017Article
- Ion channel diversity, channel expression and function in the choroid plexuses.Cerebrospinal fluid research · 2007Article
- Water and solute secretion by the choroid plexus.Pflugers Archiv : European journal of physiology · 2007Review
- Molecular mechanisms of cerebrospinal fluid production.Neuroscience · 2004Review
- Inward-rectifying anion channels are expressed in the epithelial cells of choroid plexus isolated from ClC-2 'knock-out' mice.The Journal of physiology · 2002Article
- The choroid plexuses and the barriers between the blood and the cerebrospinal fluid.Cellular and molecular neurobiology · 2000Review
- The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Inhibition of the inward-rectifying Cl- channel in rat choroid plexus by a decrease in extracellular pH.The Journal of physiology · 1997Article
- Properties of the cAMP-activated C1- current in choroid plexus epithelial cells isolated from the rat.The Journal of physiology · 1996Article
- KCNE2 and the K (+) channel: the tail wagging the dog.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The whole-cell patch-clamp technique was applied to rat choroid plexus epithelial cells. The resting membrane potential was -53 mV. The whole-cell conductance was mainly K+ selective, and the K+ current observed appeared to contain two distinct components. Depolarizing voltage pulses (more positive than 0 mV) evoked time-dependent outward currents which resembled delayed-rectifying K+ currents in other tissues. The current exhibited time-dependent activation and, at potentials more positive than 40 mV, slower time-dependent inactivation. The reversal potential measured by tail current analysis showed a shift of 43 mV for a tenfold increase in extracellular K+ concentration ([K+]o). The current was reduced by extracellular 5 mM Ba2+, 5 mM tetraethylammonium (TEA+), 5 mM Cs+ and 1 mM 4-aminopyridine (4-AP). In contrast, hyperpolarizing voltage pulses evoked time-independent, inward-rectifying currents. The reversal potential measured by voltage-ramp commands showed a shift of 42 mV for a tenfold increase in [K+]o. The chord conductance did not appear to increase with increasing [K+]o. The current was reduced by extracellular 5 mM Ba2+ and 0.5 mM Cs+, but not by 5 mM TEA+ or 1 mM 4-AP. These data suggest that two populations of K+ channel contribute to the conductance of choroid plexus epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.