ArticleThe Journal of physiology1994
Carotid sinus nerve section and the increase in plasma cortisol during acute hypoxia in fetal sheep.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Mechanisms of death in structurally normal stillbirths.Journal of perinatal medicine · 2019Observational
- The peripheral chemoreflex: indefatigable guardian of fetal physiological adaptation to labour.The Journal of physiology · 2018Review
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Expression of StAR and Key Genes Regulating Cortisol Biosynthesis in Near Term Ovine Fetal Adrenocortical Cells: Effects of Long-Term Hypoxia.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Ketamine modulates fetal hemodynamic and endocrine responses to umbilical cord occlusion.Physiological reports · 2016Article
- The fetal brain sparing response to hypoxia: physiological mechanisms.The Journal of physiology · 2016Review
- Gestational hypoxia modulates expression of corticotropin-releasing hormone and arginine vasopressin in the paraventricular nucleus in the ovine fetus.Physiological reports · 2016Article
- Early developmental conditioning of later health and disease: physiology or pathophysiology?Physiological reviews · 2014Review
- Genomics of the fetal hypothalamic cellular response to transient hypoxia: endocrine, immune, and metabolic responses.Physiological genomics · 2013Article
- Extracellular signal-regulated kinases (ERK1/2) signaling pathway plays a role in cortisol secretion in the long-term hypoxic ovine fetal adrenal near term.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Adrenocortical and adipose responses to high-altitude-induced, long-term hypoxia in the ovine fetus.Journal of pregnancy · 2012Review
- Chemoreflex activity increases prostaglandin endoperoxide synthase mRNA expression in the late-gestation fetal sheep brain.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Influence of estradiol and fetal stress on luteinizing hormone, follicle-stimulating hormone, and prolactin in late-gestation fetal sheep.Neonatology · 2011Article
- Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion.American journal of physiology. Regulatory, integrative and comparative physiology · 2007Article
- Restriction of placental growth results in greater hypotensive response to alpha-adrenergic blockade in fetal sheep during late gestation.The Journal of physiology · 2005Article
- Adrenocortical responsiveness is blunted in twin relative to singleton ovine fetuses.The Journal of physiology · 2004Article
- Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep.The Journal of physiology · 2003Article
- Cardiovascular and endocrine responses to acute hypoxaemia during and following dexamethasone infusion in the ovine fetus.The Journal of physiology · 2003Article
- Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetus.The Journal of physiology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
1. We studied the effects of acute isocapnic hypoxia on plasma concentrations of adrenocorticotrophic hormone (ACTH) and cortisol in sixteen sheep fetuses at 118-125 days of gestation (term is 147 days). Eight fetuses had their carotid sinus nerves cut (denervation); the remaining eight had these nerves left intact. 2. There were no differences in the plasma concentrations of ACTH or cortisol between intact and denervated fetuses during normoxia. 3. Whilst plasma cortisol increased in early (after 15 min) and late (after 45 min) hypoxia in intact fetuses, the rise in cortisol in denervated fetuses was delayed, increasing significantly only by late hypoxia. 4. In contrast, plasma ACTH concentrations were increased in early and late hypoxia in both intact and denervated fetuses. The rise was smaller in denervated fetuses, but was not significantly different from that in intact fetuses. 5. Our results indicate that, in the sheep fetus, carotid sinus nerve section delays the rise in plasma cortisol in response to acute hypoxia without affecting the ACTH response. Further work is needed to establish the mechanism underlying this effect of denervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.