ArticleGenetics1994
Components acting in localization of bicoid mRNA are conserved among Drosophila species.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation.Nature communications · 2017Article
- Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae.BMC genomics · 2005Article
- Evolutionary genomics of inversions in Drosophila pseudoobscura: evidence for epistasis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments.Genetics · 2003Article
- Article
- The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.Nucleic acids research · 1997Article
- Germline transformation of Drosophila virilis mediated by the transposable element hobo.Genetics · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Substantial insights into basic strategies for embryonic body patterning have been obtained from genetic analyses of Drosophila melanogaster. This knowledge has been used in evolutionary comparisons to ask if genes and functions are conserved. To begin to ask how highly conserved are the mechanisms of mRNA localization, a process crucial to Drosophila body patterning, we have focused on the localization of bcd mRNA to the anterior pole of the embryo. Here we consider two components involved in that process: the exuperantia (exu) gene, required for an early step in localization; and the cis-acting signal that directs bcd mRNA localization. First, we use the cloned D. melanogaster exu gene to identify the exu genes from Drosophila virilis and Drosophila pseudoobscura and to isolate them for comparisons at the structural and functional levels. Surprisingly, D. pseudoobscura has two closely related exu genes, while D. melanogaster and D. virilis have only one each. When expressed in D. melanogaster ovaries, the D. virilis exu gene and one of the D. pseudoobscura exu genes can substitute for the endogenous exu gene in supporting localization of bcd mRNA, demonstrating that function is conserved. Second, we reevaluate the ability of the D. pseudoobscura bcd mRNA localization signal to function in D. melanogaster. In contrast to a previous report, we find that function is retained. Thus, among these Drosophila species there is substantial conservation of components acting in mRNA localization, and presumably the mechanisms underlying this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.