ArticleGenetics1994
Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Metaphase Spindle Assembly.Biology · 2017Review
- Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays.Molecular & cellular proteomics : MCP · 2012Article
- The ins and outs of nuclear trafficking: unusual aspects in apicomplexan parasites.DNA and cell biology · 2009Review
- PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast.Molecular and cellular biology · 2008Article
- RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.The Journal of biological chemistry · 2008Article
- Differential gene expression of wheat progeny with contrasting levels of transpiration efficiency.Plant molecular biology · 2006Article
- New insights into myosin evolution and classification.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Gene set coregulated by the Saccharomyces cerevisiae nonsense-mediated mRNA decay pathway.Eukaryotic cell · 2005Article
- Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis.Current genetics · 2003Article
- An alpha-tubulin mutant demonstrates distinguishable functions among the spindle assembly checkpoint genes in Saccharomyces cerevisiae.Genetics · 2002Article
- Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly.The Journal of cell biology · 1999Review
- Article
- An alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteins.Molecular biology of the cell · 1998Article
- Article
- Nucleocytoplasmic transport of macromolecules.Microbiology and molecular biology reviews : MMBR · 1997Review
- A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microtubules in eukaryotic cells participate in a variety of nuclear and cytoplasmic structures, reflecting functional requirements and cell cycle position. We are studying the cellular regulation of microtubule assembly and organization in the yeast Saccharomyces cerevisiae. We screened for genes that when overexpressed suppress the growth phenotype of conditional mutants in alpha-tubulin that arrest with excess microtubules at the nonpermissive temperature (class 2 mutations). Here we describe one such suppressing element, called ATS1 (for Alpha Tubulin Suppressor). Overexpression of this gene rescues both the growth and microtubule phenotypes of all class 2 mutations, but not the cold-sensitive mutations that arrest with no microtubules (class 1 mutations). Deletion of ATS1 confers a modest slow growth phenotype which is slightly enhanced in strains containing both a deletion of ATS1 and a class 2 tub 1 mutation. The predicted ATS1 protein contains 333 amino acids and has considerable structural homology to the products of both the mammalian mitotic control gene RCC1 and the S. cerevisiae gene SRM1/PRP20. Overexpression of SRM1/PRP20 also suppresses class 2 mutants. The results suggest that this family of genes may participate in regulatory interactions between microtubules and the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.