ArticleThe EMBO journal1994
The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Frontiers in fungal phosphatases: molecular diversity, regulatory mechanisms, analytical methodologies, ecological significance, and prospects for sustainable utilization.Frontiers in bioengineering and biotechnology · 2026Review
- Synergistic effects of putative CaVirulence · 2024Article
- Potential Antifungal Targets forInternational journal of molecular sciences · 2022Review
- Disruption of calcineurin catalytic subunit (cnaA) in Epichloë festucae induces symbiotic defects and intrahyphal hyphae formation.Molecular plant pathology · 2018Article
- The putative flavin carrier family FlcA-C is important for Aspergillus fumigatus virulence.Virulence · 2017Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.Mycopathologia · 2014Review
- Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.G3 (Bethesda, Md.) · 2013Article
- Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.Molecular microbiology · 2011Article
- The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans.Eukaryotic cell · 2011Article
- Transcriptional effect of a calmodulin inhibitor, W-7, on the ligninolytic enzyme genes in Phanerochaete chrysosporium.Current genetics · 2010Article
- Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways.Eukaryotic cell · 2009Review
- Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.Eukaryotic cell · 2009Article
- Signalling pathways in the pathogenesis of Cryptococcus.Cellular microbiology · 2009Review
- Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.Antimicrobial agents and chemotherapy · 2008Article
- Calcium binding is required for calmodulin function in Aspergillus nidulans.Eukaryotic cell · 2002Article
- hyp loci control cell pattern formation in the vegetative mycelium of Aspergillus nidulans.Genetics · 1998Article
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Authors and funding
6 authors.
Funding
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Abstract
The gene encoding the homologue of the catalytic subunit of the Ca2+/calmodulin-regulated protein phosphatase 2B (calcineurin A) has been isolated from Aspergillus nidulans. This gene, cnaA+, is essential in this fungal system. Analysis of growth-arrested cells following gene disruption by homologous recombination reveals that they are blocked early in the cell cycle. The cnaA+ gene encodes a 2.5 kb mRNA and the deduced protein sequence is highly homologous to the calcineurin A subunit of other species. The mRNA varies in a cell cycle-dependent manner with maximal levels found early in G1 and considerably before the G1/S boundary. As calmodulin is also essential for A. nidulans cell cycle progression and levels rise before the G1/S boundary, our data suggest that calcineurin may represent a primary target for calmodulin at this cell cycle transition point.
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