ArticleThe EMBO journal1994
PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review.BMC urology · 2025Review
- BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes.Blood advances · 2022Article
- Xp11.2 Translocation Renal Cell Carcinoma WithFrontiers in oncology · 2021Article
- Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Article
- The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.Nature clinical practice. Rheumatology · 2009Review
- PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.The Journal of experimental medicine · 2005Article
- Identification and characterization of a PU.1/Spi-B binding site in the bovine leukemia virus long terminal repeat.Oncogene · 2003Article
- TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937.Genes & development · 2001Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- The GATA-1 and Spi-1 transcriptional factors bind to a GATA/EBS dual element in the Fli-1 exon 1.Oncogene · 1999Article
- PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.The EMBO journal · 1998Article
- Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.The EMBO journal · 1997Article
- Combinatorial determinants of tissue-specific transcription in B cells and macrophages.Molecular and cellular biology · 1997Article
- Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.The EMBO journal · 1996Article
- The transcription factor PU.1 is involved in macrophage proliferation.The Journal of experimental medicine · 1996Article
- Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.Molecular and cellular biology · 1996Article
- Activation of transcription by PU.1 requires both acidic and glutamine domains.Molecular and cellular biology · 1996Article
- PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Molecular and cellular biology · 1995Article
- Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism.Molecular medicine (Cambridge, Mass.) · 1995Article
- PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.Journal of cellular and molecular medicineReview
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Authors and funding
7 authors.
Funding
Abstract
Expression of the low-affinity Fc receptor for IgG (murine Fc gamma RIIIA) is restricted to cells of myelomonocytic origin. We report here the promoter structure, the proximal DNA sequences responsible for transcription of Fc gamma RIIIA in macrophages and the protein factors which interact with these sequences. A 51 bp sequence, termed the myeloid restricted region (MRR), was both necessary and sufficient for conferring cell type-specific expression in macrophages. Reporter constructs containing mutations in this sequence result in the loss of MRR activity upon transfection into the macrophage cell line, RAW264.7. Two cis-acting elements have been identified and are required for full promoter function. These same elements analyzed by EMSA define two binding sites recognized by nuclear factors derived from macrophages. A 3' purine tract (-50 to -39) within the MRR binds the macrophage and B cell-specific factor, PU.1, and a second E box-like element, termed MyE, upstream of the PU.1 box (-88 to -78) binds the HLH factors TFE3 and USF. EMSA studies using RAW cell extracts suggest that both PU.1 and MyE factors may bind simultaneously to the MRR resulting in a ternary complex that is responsible, in part, for the myeloid-specific activity of the Fc gamma RIIIA promoter.
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