ArticleThe EMBO journal1994
A member of a novel family of yeast 'zn-finger' proteins mediates the transition from stationary phase to cell proliferation.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Reorganization of budding yeast cytoplasm upon energy depletion.Molecular biology of the cell · 2020Article
- The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes.Biology open · 2015Article
- Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast.Molecular biology of the cell · 2011Article
- Candida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistance.PloS one · 2010Article
- The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeast.Molecular biology of the cell · 2006Article
- The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p.Eukaryotic cell · 2006Article
- "Sleeping beauty": quiescence in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2004Review
- Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast.Molecular biology of the cell · 2002Article
- The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network.The Journal of cell biology · 2001Article
- Multiple roles of Arf1 GTPase in the yeast exocytic and endocytic pathways.Molecular biology of the cell · 2001Article
- GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro.Molecular biology of the cell · 1999Article
- Identification of a new Pyk2 target protein with Arf-GAP activity.Molecular and cellular biology · 1999Article
- Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.The EMBO journal · 1999Article
- Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes.Genetics · 1998Article
- Article
- A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family.Journal of bacteriology · 1996Article
- Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase.Molecular and cellular biology · 1996Article
- Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain.The Journal of biological chemistry · 1996Article
- Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation.Molecular biology of the cell · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cloning and molecular characterization of the GCS1 gene from the budding yeast Saccharomyces cerevisiae show that stationary phase is in fact a unique developmental state, with requirements to resume cell proliferation that can be distinct from those for maintenance of proliferation. Deletion of the GCS1 gene products a novel phenotype: stationary-phase mutant cells do not resume proliferation at a restrictive temperature of 15 degrees C, but mutant cells lacking Gcs1p that are proliferating at the permissive temperature of 29 degrees C continue to proliferate after transfer to 15 degrees C as long as nutrients are available. The GCS1 gene sequence predicts a 39 kDa polypeptide with a novel 'Zn-finger' motif. A point mutation within the finger motif produces a phenotype that mimics that of deletion of the GCS1 gene, showing that the finger motif is essential for full Gcs1p activity. Gcs1p and the products of two newly identified genes, SPS18 and GLO3, constitute a family of novel Zn-finger proteins.
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