ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1994
Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 of Drosophila.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 56 citations in OpenAlex.
- The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells.Chromosoma · 2009Article
- Cloning, characterization and localization of Chinese hamster HP1 isoforms.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Article
- KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.Molecular and cellular biology · 1999Article
- A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophila.Molecular and cellular biology · 1999Article
- Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.The EMBO journal · 1999Article
- INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.The Journal of cell biology · 1998Article
- Autoantibodies to components of the mitotic apparatus.Molecular biology reports · 1998Review
- cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies.Clinical and experimental immunology · 1998Article
- A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells.Molecular and cellular biology · 1998Article
- A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.The EMBO journal · 1996Article
- Surprising deficiency of CENP-B binding sites in African green monkey alpha-satellite DNA: implications for CENP-B function at centromeres.Molecular and cellular biology · 1996Article
- Identification of overlapping DNA-binding and centromere-targeting domains in the human kinetochore protein CENP-C.Molecular and cellular biology · 1996Article
- DNA methylation specifies chromosomal localization of MeCP2.Molecular and cellular biology · 1996Article
- Epitope analysis of chromo antigen and clinical features in a subset of patients with anti-centromere antibodies.Molecular biology reports · 1996Article
- Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.The EMBO journal · 1995Article
- CENP-B binds a novel centromeric sequence in the Asian mouse Mus caroli.Molecular and cellular biology · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Immunofluorescence indicated that autoimmune sera from certain scleroderma/CREST patients, in addition to binding to the primary constrictions or centromeres, also labelled pericentromeric heterochromatin in mouse and human metaphase chromosomes. Immunoblotting has revealed that two conserved nuclear antigens are recognized by this CREST subgroup, one of mol. wt 26 kD (p26), and the other of mol. wt 23 kD (p23). In situ immunolabelling with affinity purified antibodies demonstrated that p26, but not p23, is concentrated in pericentromeric heterochromatin. Further studies have shown that both p26 and p23 are immunologically related to the Drosophila heterochromatin-associated protein HP1, and to other chromodomain proteins.
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