ArticleNucleic acids research1994
The yeast Saccharomyces cerevisiae DNA polymerase IV: possible involvement in double strand break DNA repair.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination.Nucleic acids research · 2023Article
- Timing of appearance of new mutations during yeast meiosis and their association with recombination.Current genetics · 2020Article
- Eukaryotic DNA Polymerases in Homologous Recombination.Annual review of genetics · 2016Review
- Consider the workhorse: Nonhomologous end-joining in budding yeast.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2016Review
- Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Mutagenesis · 2015Article
- Meiotic Recombination: The Essence of Heredity.Cold Spring Harbor perspectives in biology · 2015Review
- Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis.G3 (Bethesda, Md.) · 2013Article
- Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Genome dynamics and stability · 2008Article
- DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage.Genetics · 2006Article
- A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.Molecular and cellular biology · 1999Article
- The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- Meiotic role of SWI6 in Saccharomyces cerevisiae.Nucleic acids research · 1998Article
- Purification and characterization of a 100 kDa DNA polymerase from cauliflower inflorescence.The Biochemical journal · 1998Article
- The Pol beta-14 dominant negative rat DNA polymerase beta mutator mutant commits errors during the gap-filling step of base excision repair in Saccharomyces cerevisiae.Journal of bacteriology · 1998Article
- Article
- Evidence for a role for DNA polymerase beta in mammalian meiosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae.Journal of bacteriology · 1996Article
- Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified and purified a new DNA polymerase (DNA polymerase IV), which is similar to mammalian DNA polymerase beta, from Saccharomyces cerevisiae and suggested that it is encoded by YCR14C (POLX) on chromosome III. Here, we provided a direct evidence that the purified DNA polymerase IV is indeed encoded by POLX. Strains harboring a pol4 deletion mutation exhibit neither mitotic growth defect nor a meiosis defect, suggesting that DNA polymerase IV participates in nonessential functions in DNA metabolism. The deletion strains did not exhibit UV-sensitivity. However, they did show weak sensitivity to MMS-treatment and exhibited a hyper-recombination phenotype when intragenic recombination was measured during meiosis. Furthermore, MAT alpha pol4 delta segregants had a higher frequency of illegitimate mating with a MAT alpha tester strain than that of wild-type cells. These results suggest that DNA polymerase IV participates in a double-strand break repair pathway. A 3.2kb of the POL4 transcript was weakly expressed in mitotically growing cells. During meiosis, a 2.2 kb POL4 transcript was greatly induced, while the 3.2 kb transcript stayed at constant levels. This induction was delayed in a swi4 delta strain during meiosis, while no effect was observed in a swi6 delta strain.
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