ArticleNucleic acids research1994
Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Transcription-coupled repair of crosslinking DNA damage.DNA repair · 2025Review
- miR-34b-3p-mediated regulation of STC2 and FN1 enhances chemosensitivity and inhibits proliferation in cervical cancer.Acta biochimica et biophysica Sinica · 2024Article
- Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivities.Scientific reports · 2019Article
- Factors affecting the sensitivity of human-derived esophageal carcinoma cell lines to 5-fluorouracil and cisplatin.Oncology letters · 2013Article
- Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Initiation of DNA interstrand cross-link repair in mammalian cells.Environmental and molecular mutagenesis · 2010Review
- Treatment results of FOLFOX chemotherapy before surgery for lymph node metastasis of advanced colorectal cancer with synchronous liver metastasis: the status of LN metastasis and vessel invasions at the primary site in patients who responded to FOLFOX.International journal of clinical oncology · 2010Article
- Impaired removal of DNA interstrand cross-link in Nijmegen breakage syndrome and Fanconi anemia, but not in BRCA-defective group.Cancer science · 2008Article
- Formation and repair of interstrand cross-links in DNA.Chemical reviews · 2006Review
- Review
- Article
- Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.Molecular and cellular biology · 2000Article
- Cisplatin increases meiotic crossing-over in mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Superhelical torsion controls DNA interstrand cross-linking by antitumor cis- diamminedichloroplatinum(II).Nucleic acids research · 1996Article
- The use of alpha-DNA as an internal standard in the detection and quantitation of DNA damage in specific genes using Southern blotting.Nucleic acids research · 1996Article
- 3-methyladenine-DNA-glycosylase and O6-alkyl guanine-DNA-alkyltransferase activities and sensitivity to alkylating agents in human cancer cell lines.British journal of cancer · 1996Article
- Genomic copy number changes of DNA repair genes ERCC1 and ERCC2 in human gliomas.Journal of neuro-oncology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human excision repair gene ERCC-1 gene restores normal resistance to UV and mitomycin C in excision repair deficient chinese hamster ovary cells of complementation group 1. To investigate the involvement of the ERCC-1 gene in gene-specific repair of bulky lesions, we have studied the removal of damage induced by the antitumor agent cisplatin in CHO mutant 43-3B cells of group 1, with or without transfection with the ERCC-1 gene. Firstly, we determined the contribution of the ERCC-1 gene to the repair of interstrand crosslinks (ICL) induced by cisplatin and found efficient removal of ICLs from the dihydrofolate reductase (DHFR) gene in the ERCC-1 transfected 43-3B cells. We then assessed the contribution of ERCC-1 to the repair of intrastrand adducts (IA) induced by cisplatin. Compared to the wild-type parental cell line, the ERCC-1 transfected 43-3B cells repaired the IAs in the DHFR gene inefficiently. Thus, our data suggest that the ERCC-1 gene is more involved in the repair of interstrand crosslinks than in the removal of intrastrand adducts.
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