ArticleMolecular and cellular biology1994
Densely methylated DNA islands in mammalian chromosomal replication origins.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- DNA methylation and hydroxymethylation in stem cells.Cell biochemistry and function · 2015Review
- Mammalian Non-CpG Methylation: Stem Cells and Beyond.Biology · 2014Review
- Human non-CG methylation: are human stem cells plant-like?Epigenetics · 2010Review
- A modified protocol for bisulfite genomic sequencing of difficult samples.Biological procedures online · 2009Article
- Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix.Gene therapy & molecular biology · 2005Article
- Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection.Journal of virology · 2003Article
- Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- S1 SINE retroposons are methylated at symmetrical and non-symmetrical positions in Brassica napus: identification of a preferred target site for asymmetrical methylation.Plant molecular biology · 1999Article
- Concurrent replication and methylation at mammalian origins of replication.Molecular and cellular biology · 1998Article
- Identifying 5-methylcytosine and related modifications in DNA genomes.Nucleic acids research · 1998Review
- Lagging-strand, early-labelling, and two-dimensional gel assays suggest multiple potential initiation sites in the Chinese hamster dihydrofolate reductase origin.Molecular and cellular biology · 1998Article
- Novel pattern of DNA methylation in Neurospora crassa transgenic for the foreign gene hph.Nucleic acids research · 1997Article
- Active mammalian replication origins are associated with a high-density cluster of mCpG dinucleotides.Molecular and cellular biology · 1997Article
- p53 gene aberrations in non-small-cell lung carcinomas from a smoking population.British journal of cancer · 1997Article
- Spreading of methylation along DNA.The Biochemical journal · 1996Article
- Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.Molecular and cellular biology · 1995Article
- Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure.Molecular and cellular biology · 1995Article
- The evolution of small DNA viruses of eukaryotes: past and present considerations.Virus genes · 1995Review
- A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locus.Molecular and cellular biology · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Densely methylated DNA sequence islands, designated DMIs, have been observed in two Chinese hamster cell chromosomal replication origins by using a PCR-based chemical method of detection. One of the origins, oriS14, is located within or adjacent to the coding sequence for ribosomal protein S14 on chromosome 2q, and the other, ori-beta, is approximately 17 kbp downstream of the dhfr (dihydrofolic acid reductase) locus on chromosome 2p. The DMI in oriS14 is 127 bp long, and the DMI in ori-beta is 516 bp long. Both DMIs are bilaterally methylated (i.e., all dCs are modified to 5-methyl dC) only in cells that are replicating their DNA. When cell growth and DNA replication are arrested, methylation of CpA, CpT, and CpC dinucleotides is lost and the sequence islands display only a subset of their originally methylated CpG dinucleotides. Several possible roles for DMI-mediated regulation of mammalian chromosomal origins are considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.