ArticleMolecular and cellular biology1994
A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locus.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Codon optimization enhances protein expression of Bombyx mori nucleopolyhedrovirus DNA polymerase in E. coli.Current microbiology · 2014Article
- Human non-CG methylation: are human stem cells plant-like?Epigenetics · 2010Review
- The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units.Molecular and cellular biology · 2006Article
- The human beta-globin replication initiation region consists of two modular independent replicators.Molecular and cellular biology · 2004Article
- DNA replication efficiency depends on transcription factor-binding sites.Journal of virology · 2001Article
- Interference of the simian virus 40 origin of replication by the cytomegalovirus immediate early gene enhancer: evidence for competition of active regulatory chromatin conformation in a single domain.Molecular and cellular biology · 2000Article
- Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene initiation zone.Molecular and cellular biology · 1998Article
- Active mammalian replication origins are associated with a high-density cluster of mCpG dinucleotides.Molecular and cellular biology · 1997Article
- High-resolution mapping of the origin of DNA replication in the hamster dihydrofolate reductase gene domain by competitive PCR.Molecular and cellular biology · 1996Article
- Utilization of the same DNA replication origin by human cells of different derivation.Nucleic acids research · 1996Article
- DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells.Nucleic acids research · 1996Article
- Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells.Journal of virology · 1996Article
- Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.Molecular and cellular biology · 1995Article
- Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure.Molecular and cellular biology · 1995Article
- Modular structural elements in the replication origin region of Tetrahymena rDNA.Nucleic acids research · 1995Article
- Mapping of replication initiation sites in human ribosomal DNA by nascent-strand abundance analysis.Molecular and cellular biology · 1995Article
- Densely methylated DNA islands in mammalian chromosomal replication origins.Molecular and cellular biology · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Two complementary experimental approaches have been used to identify a chromosomal origin of bidirectional DNA replication within or immediately downstream of the Chinese hamster ribosomal protein S14 gene (RPS14). The replication origin, designated oriS14, maps within a 1.6- to 2.0-kbp region of RPS14 that includes the gene's third and fourth introns, exons IV plus V, and approximately 500 bp of proximal downstream flanking DNA. The nucleic acid sequence encoding oriS14 closely resembles the other mammalian chromosomal replication origins whose primary structures are known. It contains DNA binding sites for a large number of transcription factors, replication proteins, and mammalian oncogenes as well as several dinucleotide repeat motifs, an AT-rich region, and a sequence that is likely to bend the DNA. In contrast to the other well-characterized mammalian replication origins, which are autosomal and therefore carried as two copies per somatic cell, oriS14 is encoded by single-copy DNA within a hemizygous segment of chromosome 2q in CHO-K1 cells. Also, other known mammalian replication origins are situated in nontranscribed, intergenic DNA, whereas the DNA sequence encoding oriS14 substantially overlaps the transcribed portion of a constitutively expressed housekeeping gene.
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