ArticleJournal of clinical pathology1994
Observer variation in the histopathological classification of thymoma: correlation with prognosis.
Article in Journal of clinical pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Artificial intelligence for diagnosis and prognosis of thymic epithelial tumors: a systematic review.Mediastinum (Hong Kong, China) · 2025Review
- The impact of thymoma histotype on prognosis in a worldwide database.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
- [A review of prognostic factors in thymic malignancies].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Review
- Diagnostic reproducibility of thymic epithelial tumors using the World Health Organization classification: note for thoracic clinicians.General thoracic and cardiovascular surgery · 2013Article
- Invasive thymoma metastatic to the cavernous sinus.Surgical neurology international · 2013Article
- The role of a pseudocapsula in thymic epithelial tumors: outcome and correlation with established prognostic parameters. Results of a 20-year single centre retrospective analysis.Journal of cardiothoracic surgery · 2009Article
- Interobserver variation in histopathological assessment of Helicobacter pylori gastritis.World journal of gastroenterology · 2003Article
- Thymoma: a review of the clinical and pathological findings in 65 cases.Canadian journal of surgery. Journal canadien de chirurgie · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess the ability of three histopathologists, experienced in thoracic surgical reporting, consistently to classify thymomas as cortical, medullary, or mixed pattern tumours.
methodsThree histopathologists classified 74 thymomas (none frank carcinomas) as of either cortical, medullary, or mixed pattern, on two separate occasions. Kappa statistics were used to assess inter- and intra-observer agreement. Tumour type was compared with surgical stage as a predictor of biological behaviour.
resultsInter- and intra-observer agreement were only moderate (kappa 0.48 and 0.52, respectively). For only 26 of 74 tumours could a categorisation be consistently agreed on. Follow up information was obtained for 73 cases, with a mean follow up period of five years. The prognoses for those 26 of 74 cases appeared to be at variance from previously reported studies, and showed internal inconsistency, with the mixed pattern category showing a worse survival than the cortical category. For the group as a whole, however, stage at presentation was related to survival, with an overall five year survival of 78% (100% for stage I, 84% for stage II, 27% for stage III and 0% for stage IV).
conclusionsThe classification of thymomas into cortical, medullary, or mixed pattern tumours is difficult to apply. Surgical stage remains a better guide to prognosis.
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