ArticleThe Journal of cell biology1994
Serum-induced signal transduction determines the peripheral location of beta-actin mRNA within the cell.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 91 citations in OpenAlex.
- Microtubules in cell migration.Essays in biochemistry · 2019Review
- Posttranscriptional and Posttranslational Regulation of Actin.Anatomical record (Hoboken, N.J. : 2007) · 2018Review
- Article
- Article
- Characterization of mRNA-cytoskeleton interactions in situ using FMTRIP and proximity ligation.PloS one · 2013Article
- Control of cytoplasmic mRNA localization.Cellular and molecular life sciences : CMLS · 2012Review
- β-Actin specifically controls cell growth, migration, and the G-actin pool.Molecular biology of the cell · 2011Article
- Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function.Translational research : the journal of laboratory and clinical medicine · 2011Review
- A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexes.RNA (New York, N.Y.) · 2010Article
- A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation.The Journal of pathology · 2008Article
- HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.Leukemia · 2008Article
- ZBP1 enhances cell polarity and reduces chemotaxis.Journal of cell science · 2007Article
- Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs.The Journal of cell biology · 2007Article
- Imaging native beta-actin mRNA in motile fibroblasts.Biophysical journal · 2004Article
- Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology.BMC cell biology · 2003Article
- Identification of cellular mRNA targets for RNA-binding protein Sam68.Nucleic acids research · 2002Article
- Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions.Molecular biology of the cell · 2002Article
- The physiological significance of beta -actin mRNA localization in determining cell polarity and directional motility.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Small, efficient hammerhead ribozymes.Molecular biotechnology · 2000Article
- Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell motility is dependent upon the reorganization of the cellular cytoskeleton. Actin filaments form the major component of the cytoskeleton and respond rapidly to serum growth factors. We have previously shown that myoblasts sort the two cytoskeletal beta- and gamma-actin isoform mRNAs to different intracellular regions and that only beta-actin mRNA was associated with peripheral regions of cell motility (Hill, M.A. and P. Gunning. 1993. J. Cell Biol. 122: 825-832). We now show by in situ hybridization that 3T3 fibroblasts similarly sort actin isoform mRNAs and that peripheral beta-actin mRNA is regulated by serum. In the absence of serum, we could not detect beta-actin mRNA at the periphery. Addition of serum rapidly redistributed beta-actin mRNA to the periphery. gamma-actin mRNA distribution was not altered by serum addition at any time. Both proteins, as identified by immunochemistry with isoform-specific antibodies, were found in similar cellular structures. Serum-stimulated cell motility is mediated through the GTPase signal transduction pathway. We find that an RNA-binding protein, p62, that is part of this pathway, displays a localization pattern similar to beta-actin mRNA. Our results suggest a new biological mechanism which integrates signal transduction with the supply of an architectural component required for membrane remodeling. We propose that active transport of beta-actin mRNA to regions of cell motility is one possible objective of these signal transduction pathways.
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